NRF2 and the Hallmarks of Cancer.
By Montserrat Rojo de la Vega, E. Chapman, Donna D. Zhang. Cancer Cell, 2018
1,479 citations recorded by the source corpus.
The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established the NRF2 pathway as a driver of cancer progression, metastasis, and resistance to therapy. Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this review, we explore the roles of NRF2 in the hallmarks of cancer, indicating both tumor suppressive and tumor-promoting effects.
Subfields: Molecular Biology, Organic Chemistry
View Paper: https://www.semanticscholar.org/paper/1f844034406f64b074263fc5a71b6fb674d8ab57
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In Molecular Biology
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Citations in the corpus
- Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis (2020, background): “Consequently, pathways countering oxidative stress, particularly NRF2 signaling (30), are often activated in cancer cells.”