Parkinson's disease: from monogenic forms to genetic susceptibility factors.

By S. Lesage, A. Brice. Human Molecular Genetics, 2009

995 citations recorded by the source corpus.

Subfields: Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/6648c9f99951f2f03d85caf43e155f5c7c7c646e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

1. E. Masliah
2. E. K. Kim
3. E. Choi
4. Leslie A. Crews
5. Leonidas Stefanis

In Physiology

1. E. Masliah
2. Xiongwei Zhu
3. Ernest Arenas
4. E. K. Kim
5. E. Choi
6. Nibaldo C. Inestrosa
7. Leslie A. Crews

Citations in the corpus

• Emerging roles of Wnts in the adult nervous system (2010, background): “To date several genes have been identified as causative or as susceptibility factors (see Ref”
• Pathological roles of MAPK signaling pathways in human diseases. (2010, background): “responsible for autosomal recessive forms of PD [49].”
• Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease (2012, background): “glucocerebrosidase, ATP13A2, and Nur-related protein 1 [123,124] and neurotoxins including 1-methyl-4-phenyl-1,2,3,6-tetrahydropyradine (MPTP) and rotenone have all been associated with PD pathogenesis.”
• Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease (2015, neutral): “Approximately 5– 10% of Parkinson cases show a monogenic component with mutations in PARK1, PARK4, PARK5, PARK8, PARK11, and PARK13 associated with an autosomal dominant form, whereas mutations in PARK2, PARK6, and PARK7/DJ-1 are associated with an autosomal recessive form [466].”
• Principal Differences Analysis: Interpretable Characterization of Differences between Distributions (2015, background): “[38] Lesage S, Brice A (2009) Parkinson’s disease: from monogenic forms to genetic susceptibility factors.”
• Epidemiology and etiology of Parkinson’s disease: a review of the evidence (2011, background): “Nevertheless, the LRRK2 gene is the most common PD gene known, accounting for up to 10% of autosomal dominant PD and about 4% of sporadic PD [212].”
• Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein (2009, background): “In several forms of inherited Parkinson’s disease (PD), three missense mutations and gene multiplications have been linked to SNCA, the gene encoding -synuclein protein (2).”