Dynamics of learning-related cAMP signaling and stimulus integration in the Drosophila olfactory pathway.

By Seth M. Tomchik, Ronald L. Davis. 2009

215 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Genetics, Insect Science

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Genetics

In Insect Science

Citations in the corpus

Dopaminergic neurons write and update memories with cell-type-specific rules (2016, background): “However, animals can also learn that the CS predicts the end of an aversive US, and are consequently attracted to the CS (Tanimoto et al., 2004).”
Bruchpilot, A Synaptic Active Zone Protein for Anesthesia-Resistant Memory (2011, background): “This hypothesis may be tested in future by the identification of extrinsic neurons that are specifically required for ARM and corresponding functional imaging of memory traces (Yu et al., 2005; Mao and Davis, 2009; Tomchik and Davis, 2009; Gervasi et al., 2010).”
Distinct dopamine receptor pathways underlie the temporal sensitivity of associative learning (2019, background): “cAMP was maximally evoked when KC and DAN stimulation were synchronous, matching the timing that gave rise to the strongest depression of KC-MBON signaling (Figures 2E and 5E) and consistent with evidence that calcium-sensitive adenylate cyclases serve as molecular coincidence detectors to amplify c”
Pain-relief learning in flies, rats, and man: basic research and applied perspectives (2014, methodology): “been few studies directly suggesting a positive valence of the learned cue after relief-learning types of procedure: Walasek and colleagues (1995) used a 1-sec shock and a 1-min cue which had simultaneous onsets such that the cue outlasted the punishment by 59 sec.”
Cell Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression (2016, unknown): “…being important for STM, / KCs playing a role in memory consolidation, and / KCs being important for LTM (Blum et al., 2009; Krashes et al., 2007; Tomchik and Davis, 2009; Trannoy et al., 2011; Yu et al., 2006) – although there are exceptions to this general picture (Aso et al., 2014b; Bouzaiane…”
Reward signal in a recurrent circuit drives appetitive long-term memory formation (2015, unknown): “These results are consistent with the observation that the coincidence detector adenylate cyclase encoded by rutabaga, thought to act downstream of the dopamine receptor (Tomchik and Davis, 2009; Gervasi et al., 2010; Boto et al., 2014), functions for LTM in the α/β KCs (Trannoy et al., 2011).”
Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability (2012, background): “Considering the importance of the vertical lobes in olfactory learning [8,9,39,40,41,42], MB-MV1 neuron might act together with MB-V1 neuron during memory acquisition.”
Heterosynaptic plasticity underlies aversive olfactory learning in Drosophila (2015, unknown): “While odor-evoked calcium signals increase in KC axons (Akalal et al., 2010, 2011; Boto et al., 2014; Tomchik and Davis, 2009; Wang et al., 2008; Yu et al., 2006, but see Zhang and Roman, 2013), signals in MBONs decrease in some cases (Owald et al., 2015; Séjourné et al., 2011) and increase in…”
The Drosophila Mushroom Body: From Architecture to Algorithm in a Learning Circuit. (2020, background): “Calcium influx from olfactory input and G protein signaling initiated by dopamine receptors were proposed to combine synergistically to activate cAMP production,which leads to plasticity (Gervasi et al. 2010, Tomchik & Davis 2009).”
Spaced Training Forms Complementary Long-Term Memories of Opposite Valence in Drosophila (2019, background): “…KCs and MBONs (Séjourné et al., 2011; Hige et al., 2015; Owald et al., 2015; Perisse et al., 2016) via dopamine receptor directed cAMP-dependent plasticity (Yu et al., 2006; Kim et al., 2007; Tomchik and Davis, 2009; Qin et al., 2012; Zhang and Roman, 2013; Boto et al., 2014; Hige et al., 2015).”
Sleep facilitates memory by blocking dopamine neuron mediated forgetting (2015, unknown): “In flies, DA has been shown to elicit presynaptic plasticity within the Kenyon cells of theMBmemory center proposed to underlie learning (Tomchik and Davis, 2009).”
Are mushroom bodies cerebellum-like structures? (2011, background): “…bodies through rutabaga adenylyl cyclase activation potentiates Ca2þ influx in Kenyon cells in response to stimulation (Yu et al., 2006; Tomchik and Davis, 2009; Akalal et al., 2010), although a causal link to LTP-like synaptic plasticity in Kenyon cells remains to be demonstrated.”