Signaling and transcription in T helper development.

By K. Murphy, Wenjun Ouyang, J. Farrar, Jianfei Yang, S. Ranganath, Hélène Asnagli, M. Afkarian, T. Murphy. Annual Review of Immunology, 2000

710 citations recorded by the source corpus.

Subfields: Immunology

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Molecular aspects of the pathogenesis of periodontitis. (2015, background): “interleukin-12 receptor beta-2, reinforcing the interleukin-12-mediated T-helper 1 commitment (2, 54).”
IL-18–stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production (2001, background): “Despite numerous studies, the transcriptional regulation of expression of the gene encoding IFN-γ is only partly understoo”
Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses (2004, neutral): “dtd" [ ]> Naive CD4 + T cells differentiate toward T helper type 1 (T H 1) or T H 2 cells when stimulated through their T cell receptors by peptide presented by specialized antigen-presenting cells (APCs”
Decision making in the immune system: The lineage decisions of helper T cells (2002, neutral): “Although certain possible sources, such as NKT cells and basophils, have been considered (reviewed in Ref”
T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells (2002, neutral): “gif" NDATA ITEM> ]> T helper type 1 (T H 1) cell development involves the actions of both interferon-γ (IFN-γ) and interleukin-12 (IL-12”