IL-18–stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production

By Jianfei Yang, Hong Zhu, T. Murphy, Wenjun Ouyang, K. Murphy. Nature Immunology, 2001

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Differentiation of Effector CD4 T Cell Populations (2010, unknown): “IL-12, by activating STAT4, together with IL-18, an NF-κB activator, induces TCRindependent IFN-γ production (48, 49).”
GADD45β/GADD45γ and MEKK4 comprise a genetic pathway mediating STAT4‐independent IFNγ production in T cells (2004, methodology): “This finding differs from the results reported by Yang et al (2001), which suggests that GADD45b and MEKK4 mediate only IL12/IL18-induced, but not TCR-induced IFNg production.”
Interleukin 18 (2001, unknown): “Perspectives and Questions One of the most novel activities of IL-18 is its ability to induce Th1 effectors to produce IFN- in the absence of TCR signaling (21).”