Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles

By M. Febbraio, B. K. Pedersen. The FASEB Journal, 2002

991 citations recorded by the source corpus.

Subfields: Epidemiology, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/658f49a82183639f96831dae168c617d19184f84

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Citations in the corpus

Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans (2003, background): “In general, the plasma cytokines found following exercise suggest that exercise induces a strong antiinflammatory effect (15).”
The anti-inflammatory effect of exercise. (2005, background): “The cytokine response to exercise differs from that elicited by severe infections (33, 98, 100, 138).”
Evidence for prescribing exercise as therapy in chronic disease (2006, background): “Physical training appears to induce anti-inflammation and specifically inhibit TNF production (Pedersen et al., 2001; Febbraio & Pedersen, 2002).”
Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase (2006, background): “It is well known that IL-6 is rapidly released into the circulation following exercise (32).”
So depression is an inflammatory disease, but where does the inflammation come from? (2013, positive): “Contr acti g skeletal muscle produces a number of ‘myokines’, such as IL-6 [95], which impact systemical ly on lipid and glucose metabolism [96].”
FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis During Aging (2010, background): “For example, interleukin-6 (IL-6) is produced by muscles and has been proposed to control glucose homeostasis and feeding behavior through peripheral and brain mechanisms (Febbraio and Pedersen, 2002; Plata-Salaman, 1998).”
Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases (2015, background): “Physical training increases the diastolic filling of the left ventricle (Kelemen et al., 1990; Levy et al., 1993), increases the endothelial vasodilatory function (Higashi et al., 1999a, b) and induces anti-inflammatory effects (Febbraio & Pedersen, 2002).”
Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase (2009, background): “Unlike the cytokine IL-6, which is upregulated by muscle contractions, leading to altered liver [9] and adipose tissue [42] metabolism, our data suggest that contractioninduced muscle-derived BDNF does not act in a hormonelike manner.”
Age-related inflammatory cytokines and disease. (2003, background): “demonstrated that the production of muscle-derived IL-6 is not linked to HSP70 [152,154].”
AMPK in Health and Disease. (2009, methodology): “While IL-6 is elevated with obesity, the discovery that IL-6 can be produced and released from skeletal muscle during exercise (143) suggested a possible alternative role of IL-6 in regulating metabolism.”
Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020, background): “During muscle work, IL-6 is produced by human contracting skeletal muscle and released into the blood (114) in a TNF-independent fashion (115).”
Role of myokines in exercise and metabolism. (2007, background): “The level of circulating IL-6 increases in an exponential fashion (up to 100-fold) in response to exercise, and it declines in the postexercise period (18, 37, 75).”