Hierarchical recruitment of polycomb group silencing complexes.

By Liangjun Wang, J. L. Brown, R. Cao, Yi Zhang, J. A. Kassis, Richard S. Jones, Jeffrey A. Simon, Michael L. Atchison, Haiming Chen, Robin R Harrod and 1 more. Molecules and Cells, 2004

595 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6554b691477d4c3da409588ee95654e80fa780fc

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In Molecular Biology

1. Yi Zhang
2. D. Reinberg
3. J. Simon
4. R. Cao
5. Robert E. Kingston
6. Y. Tsukada
7. R. Klose
8. Paul Tempst

Citations in the corpus

• The diverse functions of histone lysine methylation (2005, background): “Based on the analyses of entire chromosomes as well as individual genes, it seems that trimethyl-H3-K27 is enriched at silenced homeotic genes, the inactive X-chromosome and imprinted genes 64,72,73,76,77 .”
• Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms (2008, background): “Given this, PRC1 was proposed to act downstream of PRC2 (Wang et al., 2004b).”
• Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15INK4B tumor suppressor gene (2010, background): “Previous genetic and biochemical studies suggest a hierarchical recruitment model where PRC2mediated H3K27 methylation is required for recruitment of PRC1, which causes H2A-K119 ubiquitination on the Hox gene cluster both in fly and human cells (Wang et al., 2004; Cao et al., 2005).”
• Polycomb silencers control cell fate, development and cancer (2006, background): “Transcriptional repression by PRCs The precise molecular mechanisms of PRC-mediated repression are still poorly understood, but it has been suggested that the complex can inhibit transcription by preventing ATP-dependent nucleosome remodelling by the SWI/SNF complex as well as by directly block”
• Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation (2014, background): “The co-occupancy of polycomb group proteins at target sites has largely been viewed in the context of a hierarchical recruitment model (Cao et al., 2002; Wang et al., 2004b).”
• Role of histone H2A ubiquitination in Polycomb silencing (2004, background): “4b ), sites at which E(Z) and PC, another PRC1 core component, have previously been shown to be locate”
• Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (2005, methodology): “Accumulating evidence supports a sequential model (Wang et al., 2004b) in which ESC-E(Z)-mediated H3-K27 methylation serves as a binding site for the recruitment of the PRC1 complex through the specific recognition of the H3-K27 methyl mark by the chromo domain of the Poly-comb (Pc) protein (Fischle…”
• Mechanisms of Polycomb gene silencing: knowns and unknowns (2009, methodology): “The function of PHO as a recruiter is supported by ChIP studies in which both PRC1 and PRC2 are lost from a Hox gene PRE if PHO or PHOL is disrupte”
• Genome Regulation by Polycomb and Trithorax: 70 Years and Counting. (2017, unknown): “Initially, a hierarchical recruitment model was proposed in which TFs recruit PRC2, which subsequently recruits PRC1 via the interaction of Polycomb (Pc/CBX) with the PRC2-deposited H3K27me3 mark (Figure 2A) (Wang et al., 2004).”