Memory Consolidation of Auditory Pavlovian Fear Conditioning Requires Protein Synthesis and Protein Kinase A in the Amygdala

By G. Schafe, Joseph E LeDoux. Journal of Neuroscience, 2000

615 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/651a5d0ab75e64246985a3d596b01031a0e903a3

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Citations in the corpus

Role of adrenal stress hormones in forming lasting memories in the brain. (2002, background): “Auditory fear conditioning is attenuated by administration of a PKA inhibitor directly into the BLA [26], and consolidation of fear memories is impaired in transgenic mice that overexpress an inhibitory isoform of PKA [27], suggesting a crucial role for PKA in memory consolidation.”
Can Playing the Computer Game “Tetris” Reduce the Build-Up of Flashbacks for Trauma? A Proposal from Cognitive Science (2009, background): “In rats, the consolidation of fear memories can be inhibited in a dose dependent fashion with administration of either anisomycin or Rp-cAMPS in the immediate post-training phase [34].”
Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning. (2001, background): “…memory of fear conditioning can also be dissociated by blockade of several second-messenger pathways in LA or more globally, including the mitogen-activated protein kinase (MAPK) and protein kinase A (PKA) pathways (Bourtchouladze et al. 1998; Schafe et al. 1999, 2000; Schafe and LeDoux 2000).”
Cellular and systems reconsolidation in the hippocampus. (2002, neutral): “the rememory (LTM) (Schafe and LeDoux, 2000).”
The amygdala modulates the consolidation of memories of emotionally arousing experiences. (2004, background): “…fear conditioning (LaLumiere et al. 2003, Sacchetti et al. 1999, Vazdarjanova & McGaugh 1999), cued fear conditioning (Sacchetti et al. 1999, Schafe & LeDoux 2000), Y-maze discrimination training (McGaugh et al. 1988), change in reward magnitude (Salinas et al. 1997), conditioned place…”
Contributions of the amygdala to emotion processing: from animal models to human behavior. (2005, background): “For example, in a fear-conditioning paradigm, disruption of protein synthesis in the lateral amygdala immediately after training (Schafe and LeDoux, 2000) or immediately after retrieval of the CS (Nader et al., 2000) has no effect on the CR for several hours but then prevents the expression of the…”
Persistence of long-term memory storage requires a late protein synthesis- and BDNF- dependent phase in the hippocampus. (2007, positive): “Many behavioral studies in different animal species have demonstrated that LTM requires de novo protein synthesis around the time of training or during the first few hours posttraining (Bourtchouladze et al., 1998; Davis et al., 1976; Flood et al., 1975; Ghirardi et al., 1995; Grecksch and Matthies,”
Rapid Consolidation to a radish and Protein Synthesis-Dependent Long-Term Memory after Single-Session Appetitive Olfactory Conditioning in Drosophila (2008, background): “A single appetitive training session forms memory that requires new protein synthesis A hallmark of LTM in all organisms is a requirement for new protein synthesis after training (McGaugh, 1966; Daniels, 1971; Jaffe, 1980; Davis and Squire, 1984; Mizumori et al., 1985; Montarolo et al., 1986; Rose a”
Memory engrams: Recalling the past and imagining the future (2020, background): “Inhibiting protein synthesis before or immediately after an experience is known to induce amnesia (151, 152) and block cellular consolidation (153–155).”
A single standard for memory: the case for reconsolidation (2009, background): “c A typical demonstration of a consolidation blockade [108].”
Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear (2010, neutral): “In contrast, early LTP and short-term fear memory were spared (165, 167, 449, 452).”