The role of orphan nuclear receptors in the regulation of cholesterol homeostasis.

By J. Repa, D. Mangelsdorf. Annual Review of Cell and Developmental Biology, 2000

793 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/650cdccbbf49ac87bac2466415afed6c2c840616

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. P. Tontonoz
2. D. Mangelsdorf

In Oncology

1. P. Tontonoz
2. J. Goldstein
3. D. Mangelsdorf
4. Michael S. Brown
5. S. Bensinger
6. A. Calkin
7. N. Zelcer
8. P. Edwards

In Surgery

1. P. Tontonoz
2. J. Goldstein
3. Michael S. Brown
4. D. Mangelsdorf
5. A. Calkin
6. S. Bensinger
7. N. Zelcer
8. P. Edwards

Citations in the corpus

• Integration of metabolism and inflammation by lipid-activated nuclear receptors (2008, background): “LXR-α and LXR-β have considerable sequence homology (∼77p identity in DNA- and ligand-binding domains), seem to respond to the same endogenous ligands, and have almost identical target gene”
• Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR (2012, background): “LXRα is expressed in tissues with a high metabolic activity, including liver, adipose and macrophages, whereas LXRβ is ubiquitously expresse”
• Protein sensors for membrane sterols. (2006, neutral): “In cultured cells, LXRs are potently activated by three oxysterols: 24(S),25-epoxycholesterol, 22(R)-hydroxycholesterol, and 27-hydroxycholesterol (Repa and Mangelsdorf, 2000).”
• Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ (2000, methodology): “Recently, a synthetic nonsteroidal LXR agonist has also been described (Repa et al. 2000; Schultz et al. 2000).”
• LXR signaling couples sterol metabolism to proliferation in the acquired immune response (2008, background): “LXRa is highly expressed in liver, adipose tissue, and macrophages, and LXRb is expressed ubiquitously (Repa and Mangelsdorf, 2000).”
• Thematic review series: Brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal Published, JLR Papers in Press, May 16, 2004. DOI 10.1194/jlr.R400004-JLR200 (2004, background): “In cells such as macrophages, this desorption process may be under the control of ABCA1, but this seems not to be the case with most other cell types (40).”