Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity
By G. Wayman, Y. Lee, Hiroshi Tokumitsu, Alcino J. Silva, T. Soderling. Neuron, 2008
608 citations recorded by the source corpus.
In the nervous system, many intracellular responses to elevated calcium are mediated by CaM kinases (CaMKs), a family of protein kinases whose activities are initially modulated by binding Ca2+/calmodulin and subsequently by protein phosphorylation. One member of this family, CaMKII, is well-established for its effects on modulating synaptic plasticity and learning and memory. However, recent studies indicate that some actions on neuronal development and function attributed to CaMKII may instead or in addition be mediated by other members of the CaMK cascade, such as CaMKK, CaMKI, and CaMKIV. This review summarizes key neuronal functions of the CaMK cascade in signal transduction, gene transcription, synaptic development and plasticity, and behavior. The technical challenges of mapping cellular protein kinase signaling pathways are also discussed.
Subfields: Cell Biology, Cellular and Molecular Neuroscience
View Paper: https://www.semanticscholar.org/paper/cf15853f02f4f7218636cd5e9da048c4e01c1ae4
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In Cellular and Molecular Neuroscience
Citations in the corpus
- TrkB signalling pathways in LTP and learning (2009, background): “For example, CaMKII autophosphorylation has been shown to be essential for LT”
- From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function. (2008, background): “Overexpression of miRNA132 increases, while blocking miRNA132 function decreases, neurite growth (Vo et al., 2005). miRNA132 controls dendritic growth by regulating the translation of p250GAP, a protein that affects actin cytoskeletal dynamics (Wayman et al., 2008a).”
- Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear (2010, unknown): “The -isoform of CaMKII is considered a key mediator of synaptic plasticity and associative learning in a variety of brain regions and species (520).”