A guide to immunometabolism for immunologists

By Luke A. O'Neill, Rigel J. Kishton, J. Rathmell. Nature reviews. Immunology, 2016

2,761 citations recorded by the source corpus.

In recent years a substantial number of findings have been made in the area of immunometabolism, by which we mean the changes in intracellular metabolic pathways in immune cells that alter their function. Here, we provide a brief refresher course on six of the major metabolic pathways involved (specifically, glycolysis, the tricarboxylic acid (TCA) cycle, the pentose phosphate pathway, fatty acid oxidation, fatty acid synthesis and amino acid metabolism), giving specific examples of how precise changes in the metabolites of these pathways shape the immune cell response. What is emerging is a complex interplay between metabolic reprogramming and immunity, which is providing an extra dimension to our understanding of the immune system in health and disease.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/64a05bae5e94f539543aaa21da39079b9ebe9bfb

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In Immunology

1. W. Zou
2. Ilona Kryczek
3. Shuang Wei
4. F. Munari
5. R. Sánchez-Rodríguez
6. Tommaso Scolaro
7. S. Ghosh
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Citations in the corpus

• The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. (2020, background): “The cycle generates energy equivalent to ATP (that is, GTP) as well as both NADH and FADH2, which serve as important electron carriers for electron transport chain-oxidative phosphorylation, resulting in the generation of ATP (Han et al., 2016).”
• CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy (2019, background): “Tumor metabolism contributes to immune evasion via inducing T cell dysfunction and exclusion 24,25 .”
• Autophagy in inflammation, infection, and immunometabolism (2021, background): “AMPK and mTOR work as the yin and the yang of cellular metabolism, and act in opposing ways to control both autophagy (Herzig and Shaw, 2018; Liu and Sabatini, 2020) and immunometabolism, profoundly affecting immune cell function (O’Neill and Hardie, 2013; O’Neill et al., 2016; Weichhart et al., 201”
• Metabolic Instruction of Immunity (2017, neutral): “Both mTORC1 and HIF-1α promote aerobic glycolysis (O’Neill et al., 2016).”
• The Metabolic Signature of Macrophage Responses (2019, methodology): “Notably, the FAS pathway permits the generation of lipids by using different precursors of TCA cycle, glycolysis and PPP pathway (149).”