The magic glue hyaluronan and its eraser hyaluronidase: a biological overview.

By K. Girish, K. Kemparaju. Life Science, 2007

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Therapeutic Strategies for Enhancing Angiogenesis in Wound Healing (2018, background): “In an injured or disease state, aberrant conditions can cause the degradation of high molecularweight by hyaluronidases andROS into lowmolecularweight HA which further depolymerized to form oligomeric HA [293,294].”
Hyaluronic Acid in the Third Millennium (2018, background): “Indeed, high molecular weight (HMW) and low molecular weight (LMW) hyaluronan can even display opposite effects [51,60], and when they are simultaneously present in a specific tissue, they can exert actions different from the simple sum of those of their separate size-related effects [51].”
Mammalian glycosylation in immunity (2008, neutral): “The enzymatic regulation of hyaluronan synthesis and degradation is increasingly recognized as having an important role in innate immunity and the response to infectio”