Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics

By T. Padera, A. Kadambi, E. di Tomaso, C. M. Carreira, E. Brown, Y. Boucher, N. Choi, D. Mathisen, J. Wain, E. Mark and 2 more. Science, 2002

988 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/644dee7ed0dfc1488ebe25ce7b5e94470c8d7d3b

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Citations in the corpus

Angiogenesis: Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma (2003, background): “Lymphangiogenesis often accompanies angiogenesis, and this field of research is now gaining momentum with new research tool”
AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. (2005, background): “Additional activity is observed against the kinase associated with Flt-1 (IC 50 = 5 nmol/L) and the VEGF-C and VEGF-D receptor Flt-4 (IC 50 V 3 nmol/L).”
VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. (2004, background): “” Journal of Clinical Investigation 113 (7) (April 1): 1040–1050.”
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment (2010, background): “The invasive margin is a critical area for stimulation of angiogenesis and lymphangiogenesis in tumors, which contributes to tumor invasion and metastasis (Padera et al., 2002).”
Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize (2007, background): “Consequently, there are no functional lymphatic vessels inside solid tumors [Leu et al., 2000; Padera et al., 2002].”
Lymphangiogenesis in development and human disease (2005, background): “We favour the view that local lymphatic vessels at the tumour margin are more important for spreading tumour cells, through the process of vessel sprouting under the influence of interstitial fluid hypertension and tumour-secreted VEGF-”
Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents. (2009, background): “Although recent discoveries in the biology of lymphatics have emphasized their key roles in immunity as well as the development of many disease”
Delivering nanomedicine to solid tumors (2010, background): “Therefore, functional lymphatic vessels exist only in the tumor periphery”
High interstitial fluid pressure — an obstacle in cancer therapy (2004, background): “Moreover, lymphatic vessels are absent or non-functional in tumour”
Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. (2012, background): “Other possible factors that may contribute to the high Pif are the lack of functioning lymphatics in central tumor areas (262, 350), intratumoral blood vessel compression due to solid stress from the growing tumor (351), and direct effects of growth factors like PDGF, TGF- , and VEGF (187).”
Intravital imaging of cell movement in tumours (2003, background): “has allowed for much greater depth of penetration of tissue for imaging and has greatly decreased the amount of photobleaching and photodamag”