Metabolism and functions of glutathione in brain.

By R. Dringen. Progress in neurobiology, 2000

1,739 citations recorded by the source corpus.

Subfields: Biochemistry, Biological Psychiatry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6443f825fea988fefcb2872eda1bda82af69424f

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Citations in the corpus

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway (2014, background): “GSH is in turn employed as electron donor for the reduction of detrimental peroxides (ROOH) by glutathione peroxidase (GPx) (Dringen, 2000).”
Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. (2011, background): “Cultured astrocytes release large amounts of GSH into the extracellular space—up to 10% of their total content within 1 hr (Dringen, 2000).”
Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024, background): “133 Adults with MDD exhibit ROS-mediated reductions in nitric oxide (NO)-dependent dilation.”
Mitochondria and neuronal activity. (2007, background): “Under certain conditions, it might be also influenced by extramitochondrial signaling and antioxidative processes, where NADH and NADPH serve as cofactors (14, 54, 110).”
Astrocytes and Brain Injury (2003, background): “Glutathione is the principal antioxidant in brain (Dringen, 2000), and brains depleted of glutathione are more sensitive to ischemic injury (Mizui et al.”
The Role of Oxidative Stress in Neurodegenerative Diseases (2015, background): “GSH can be regenerated from glutathione disulfide by the reaction with glutathione reductase that transfers electrons from NADPH to glutathione disulfide [54, 55].”
Glutamate as a neurotransmitter in the healthy brain (2014, background): “Another reason for the interest is that cystine is a source of cysteine needed for synthesis of glutathione (Dringen 2000).”
Astrocyte reactivity and reactive astrogliosis: costs and benefits. (2014, background): “In neurotrauma or ischemic stress, activated astrocytes limit oxidative damage to neurons by a glutathione-dependent mechanism (61).”
Astrocyte activation and reactive gliosis (2005, background): “Astrocytes also play a crucial part in the antioxidant defense of the brain, containing the highest concentrations of antioxidants as well as providing the neurons with substrates for antioxidants such as glutathione (Dringen, 2000; Dringen et al., 2002).”
The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities (2013, positive): “Extracellular GSH is metabolized by the ectoenzyme cglutamyl transferase (GGT), which transfers the c-glutamyl residue to different acceptor amino acids, leading to the formation of a c-glutamyl containing dipeptide and the dipeptide cysteinyl glycine, which is either cleaved by extracellular dipept”