IL-13 effector functions.

By TA Wynn. Annual Review of Immunology, 2003

1,043 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/63740e7dcfc8af34f0c10f33b843b7cb0399449a

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Citations in the corpus

Cellular and molecular mechanisms of fibrosis (2008, background): “During this period, lymphocytes and other cells become activated and begin secreting profibrotic cytokines and growth factors, such as TGFβ, IL-13 and PDGF [6–8], which further activate the macrophages and fibroblasts.”
Systemically dispersed innate IL-13–expressing cells in type 2 immunity (2010, background): “Despite these observations, these cytokines also have more dedicated functions during a type 2 response, with IL-4 facilitating humoral IgG1 and IgE production (3) and IL-13 contributing to epithelial hyperplasia and eosinophil recruitment in peripheral tissues (32).”
Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy (2016, background): “This cytokine, by secretion of matrix metalloproteinase, has anti-inflammatory properties especially during allergic inflammation (20).”
Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis (2009, background): “Consequently, depending on the duration and magnitude of the infection, Th2 cytokines exhibit both protective (IL-4, acute infections) and pathogenic (IL13, chronic infections) activity in the mouse model of schistosomiasis [40,41].”
Macrophage plasticity and polarization: in vivo veritas. (2012, neutral): “IL-4–driven M2 polarization is likely to play a key role as an orchestrator of these processes (77).”
IL-13 signaling through the IL-13α2 receptor is involved in induction of TGF-β1 production and fibrosis (2006, background): “In addition, in the context of IL-13–induced fibrosis occurring in IL-13Rα 2 –deficient mice with schistosomiasis, one observes greatly increased fibrosis, presumably resulting from increased signaling through the IL-4Rα–IL-13Rα 1 complex in the absence of soluble IL-13Rα 2 functioning as a deco”
Fibroblasts in fibrosis: novel roles and mediators (2014, background): “This response requires the migration of endothelial cells to construct tubes through the ground substance of connective tissue (Dunn et al., 2000).”
Macrophage plasticity and polarization in tissue repair and remodelling (2013, background): “IL-4/IL-13-driven M2 polarization is likely to play a key role in orchestrating these processes [110], although cells with mixed phenotypes are present in situ [111].”
Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation (2014, background): “IL-13 is known to be a pro-Th2 cytokine (Wynn, 2003).”
Repertoire of microglial and macrophage responses after spinal cord injury (2011, background): “These macrophages are required to deal with extracellular pathogens such as parasites and fungal infection”
CD4+T Cells: Differentiation and Functions (2012, background): “The key effector-cytokines include IL4, IL5, IL9, IL13, IL10, IL25, and amphiregulin.”
Treatment strategies for allergy and asthma (2008, background): “The numerous functions of IL-13 in regulating IgE production, eosinophilic inflammation, airway-smooth-muscle hyperplasia, the induction of goblet-cell hyperplasia with mucus production, and the recruitment of monocytes, macrophages and T cells into the airway spaces make it a key therapeutic target”