IL-13 signaling through the IL-13α2 receptor is involved in induction of TGF-β1 production and fibrosis

By S. Fichtner‐Feigl, W. Strober, K. Kawakami, R. Puri, A. Kitani. Nature Medicine, 2006

650 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/510b4af8e2502bd31b7dcbedd858a78c7ff1a66d

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In Immunology

1. TA Wynn
2. S. Gordon
3. F. Martínez
4. R. Flavell
5. M. Wilson
6. Shomyseh Sanjabi
7. F. Powrie
8. I. Junttila

Citations in the corpus

• Alternative activation of macrophages: mechanism and functions. (2010, background): “The IL-13Ra2 chain, thought to form a decoy receptor with extraordinary affinity for IL-13 (Lupardus et al., 2010), but with little signaling capacity, has been implicated in STAT6-independent fibrogenesis and tumor-host interactions (Fichtner-Feigl et al., 2006, 2008b).”
• Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes (2018, positive): “Indeed, Fichtner-Feigl and colleagues showed a role for IL-13Rα2-mediated signaling that required the cytoplasmic tail of IL-13Rα2 in the production of TGF-β1 providing evidence for IL-13Rα2-mediated signaling (30).”
• Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease. (2019, background): “via the IL-13Rα2 subunit as blocking of IL-13Rα2 leads to a reduction of TGF-β1 expression and amelioration of fibrosis (Fichtner-Feigl et al., 2006).”
• The polarization of immune cells in the tumour environment by TGFβ (2010, background): “It is unclear how TGFβ production is induced in MDSCs and macrophages, but the mechanism might involve IL-13 and glucocorticoid”
• Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent (2010, background): “Unexpectedly, although small interfering RNA gene silenc­ ing studies implicated IL­13 in the mechanism of BLM­ induced pulmonary fibrosis (Fichtner­Feigl et al., 2006), our studies conducted with C57BL/6 il13/ and il13R2/ mice failed to reveal a significant role for IL­13 signaling at this ear”