MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles.

By Hongjae Sunwoo, Marcel E. Dinger, J. Wilusz, Paulo P. Amaral, John S. Mattick, David L. Spector. Genome Research, 2009

629 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/630dcdac3e11e83af4f65d9da5f2d599afa62a20

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

tRNA biology charges to the front. (2010, background): “2006; Yang and Altman 2007), whereas, in vertebrates, RNase P has been shown to process both the MALAT RNA and the Men b transcript (Wilusz et al. 2008; Sunwoo et al. 2009).”
The Genetic Signatures of Noncoding RNAs (2009, background): “Specific subcellular localization [19–22,52,56]”
Long noncoding RNAs: functional surprises from the RNA world. (2009, background): “…2006; Mercer et al. 2008), localize to specific subcellular compartments (Hutchinson et al. 2007; Sone et al. 2007; Clemson et al. 2009; Sasaki et al. 2009; Sunwoo et al. 2009), and are associated with human diseases (for review, see Costa 2005; Szymanski et al. 2005; Prasanth and Spector 2007).”
The multidimensional mechanisms of long noncoding RNA function (2017, background): “By contrast, other lncRNAs have been found to form specific nuclear structures, such as the lncRNAs NEAT1 and MALAT1 involved in the nucleation of paraspeckles [14, 15, 109] and nuclear speckles [110], respectively.”
Noncoding RNA:RNA Regulatory Networks in Cancer (2018, background): “2 kb transcript which localizes primarily to nuclear paraspeckles and plays an important structural role in paraspeckle formation and maintenance [83,84].”
The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation (2010, background): “Examples of some of the characterized long nrRNAs include Xist and Tsix in mammals and RoX RNAs in fruit flies, all of which are involved in dosage compensation (Prasanth and Spector, 2007); and MEN epsilon/b (NEAT1), implicated in paraspeckle structure maintenance (Chen and Carmichael, 2009; Clemso”
Long noncoding RNAs: Cellular address codes in development and disease (2013, positive): “Upon transcription of NEAT1, diffusible components of this domain nucleate at the site of NEAT1 accumulation, leading to the formation of the Paraspeckle (Figure 3A) (Chen and Carmichael, 2009; Clemson et al., 2009; Mao et al., 2011; Sasaki et al., 2009; Shevtsov and Dundr, 2011; Sunwoo et al., 2009”
The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression (2012, background): “Interestingly, the longest lncRNA is NEAT1, a single-exon lincRNA of 22.7 kb, which was recently shown to be necessary for the formation of nuclear paraspeckles (Sunwoo et al. 2009).”
LNCcation: lncRNA localization and function (2021, background): “In another example, the wellstudied GAS5 lncRNA has also been shown to be degraded through NMDwhen it is associated with ribosomes, owing to the presence of premature stop codons (Smith and Steitz, 1998; Tani et al., 2013).”
Biogenesis and Function of Nuclear Bodies (2011, background): “Studies to understand paraspeckle assembly turned to analyses of Men ε/β ncRNAs, as the depletion of these ncRNAs results in paraspeckle disassembly [14-18].”