Necroptosis in development, inflammation and disease

By R. Weinlich, A. Oberst, H. Beere, Douglas R. Green. Nature reviews. Molecular cell biology, 2016

891 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6238aa87315018704a8ebfdff03c602ddad92fab

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Citations in the corpus

Immunogenic cell stress and death (2022, background): “Along similar lines, malignant cells can subvert CALR signaling by (1) preventing PERK activation via V-set domain containing T cell activation inhibitor 1 (VTCN1, best known as B7-H4)151, (2) retaining CALR intracellularly upon interactions with stanniocalcin 1 (STC1)152, (3) limiting CALR binding ”
Copper induces cell death by targeting lipoylated TCA cycle proteins (2022, background): “Cell death involves signaling cascades and molecularly-defined effector mechanisms (20) involving proteins and lipids such as those characteristic of apoptosis (21), necroptosis (22), pyroptosis (23) and ferroptosis (24), which is a recently discovered iron-dependent cell death pathway.”
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “, organelle swelling and ruptured plasma membrane).(137,138) Necroptosis appears to be a backup mechanism of apoptosis, in which a key component of necroptosis, necrosome, assembles in TNFR1 stimulation in response to viral infection when CASP8 involved in apoptosis is inhibited.”
Pattern Recognition Receptors and the Host Cell Death Molecular Machinery (2018, background): “However, it is important to note that, as mentioned above, RIPK3 and MLKL were shown to participate of additional signaling platforms, including inflammasome activation, NF-κB signaling and even apoptosis induction (134).”
Inflammation and Cancer: Triggers, Mechanisms and Consequences (2019, background): “Moreover, many tumors are deficient in apoptotic cell death and therefore cell death by necrosis may be more immunostimulatory (Galluzzi et al., 2018; Weinlich et al., 2017).”
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “Thus, RCD stands out as a major therapeutic target for the management of multiple human disorders [1, 2, 649, 1043].”