The Promise and Perils of Wnt Signaling Through β-Catenin

By R. Moon, B. Bowerman, Michael Boutros, Norbert Perrimon. Science, 2002

941 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/62081e924eeade6c7dfd21c1e23880b760e10c42

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In Molecular Biology

Citations in the corpus

Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity (2003, background): “In the Wnt pathway, GSK-3 is part of an axin–Apc–β-catenin complex, and Wnt induces inactivation of GSK-3, stabilization of β-catenin and induction of gene transcriptio”
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation (2003, background): “Recent studies have also shown that Wnt signaling may regulate the maintenance and differentiation of stem cells (Taipale and Beachy, 2001; Moon et al., 2002).”
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface (2003, background): “For overviews of Wnt and Hh pathways within cells, an aspect that will not be presented here, the reader is referred to various other reviews (Bienz and Clevers, 2000; Cadigan and Nusse, 1997; Ingham, 2001; Ingham and McMahon, 2001; Kalderon, 2000; Kalderon, 2002; McMahon, 2000; Moon et al., 2002 )”
Mechanisms underlying differential responses to FGF signaling. (2005, background): “However, in the presence of a Wnt signal, GSK-3b is inactivated by phosphorylation, bcatenin is not degraded, and then enters the nucleus where, through binding to members of the LEF/TCF family of transcription factors, it activates transcription of Wnt-target genes (for a review see [98]).”
Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis (2005, background): “GSK3 is a key component of the Wnt signalling pathway controlling b-catenin levels and transcriptional responses required for development and cell growth (Moon et al, 2002; Nelson and Nusse, 2004).”
Interactions between Sox9 and β-catenin control chondrocyte differentiation (2004, background): “-Catenin is also a downstream intracellular signaling molecule in the canonical Wnt pathway, which controls cell differentiation, cell proliferation, and cell migration in many aspects of embryonic development (Huelsken and Birchmeier 2001; Moon et al. 2002).”
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways (2005, background): “After translocation to the nucleus, β-catenin interacts with TCF family members, activating Wnt target gene”