Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

By M. Simons, J. Gloy, A. Ganner, Axel Bullerkotte, M. Bashkurov, C. Krönig, B. Schermer, T. Benzing, O. A. Cabello, A. Jenny and 5 more. Nature Genetics, 2005

798 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/093e05fa2f24d3a6dca2f0254bb08bad9ec0cba3

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In Genetics

1. Christof Niehrs
2. R. Nusse
3. S. Angers
4. P. Beales
5. Hans Clevers

In Molecular Biology

1. R. Nusse
2. Christof Niehrs
3. S. Angers
4. R. Moon
5. Cristina Cruciat
6. Hans Clevers
7. G. Schulte
8. J. Petersen

Citations in the corpus

• HEF1-dependent Aurora A activation induces disassembly of the primary cilium. (2007, positive): “Notably, recent studies have shown that the Hedgehog, Wnt, PDGF, and other signaling cascades are coordinated at cilia (Cano et al., 2004; Huangfu and Anderson, 2005; Liu et al., 2005; Schneider et al., 2005; Simons et al., 2005; Tanaka et al., 2005).”
• Secreted and transmembrane wnt inhibitors and activators. (2013, background): “Inhibition of PCP signaling, which antagonizes Wnt/b-catenin signaling (Yan et al. 2001; Schwarz-Romond et al. 2002; Simons et al. 2005; Li et al. 2011), may also explain why sFRPs can activate Wnt/b-catenin signaling (Swain et al.”
• Proximal events in Wnt signal transduction (2009, background): “The first clue that cilia are important for Wnt signalling came from the observation that kidneys from inversin knockout mice have a phenotype that is reminiscent of mice with dysregulated Wnt–β-catenin signallin”
• Towards an integrated view of Wnt signaling in development (2009, background): “Other proteins, such as Nkd, Inversin and Diversin, have been considered to function as molecular ‘switches’, by inhibiting one intracellular response and promoting another (Schwarz-Romond et al., 2002; Simons et al., 2005; Yan et al., 2001), and they too might be prime examples of nodes in the netw”
• Ciliopathies: an expanding disease spectrum (2011, background): “Previous studies have shown a role for cilia in mediating the switch between canonical and non-canonical Wnt signalling [18].”