Deacetylase inhibition promotes the generation and function of regulatory T cells

By R. Tao, E. F. Zoeten, Engin Özkaynak, Chunxia Chen, Liqing Wang, Paige M. Porrett, Bin Li, L. Turka, E. Olson, M. Greene and 2 more. Nature Medicine, 2007

940 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f68443c9e758e65db49ce3147fc56de5a7b39753

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Citations in the corpus

Foxp3 reprograms T cell metabolism to function in low glucose high lactate environments (2017, methodology): “Paired Student’s t test; *, **, and *** indicate p < 0.05, p < 0.01, and p < 0.001, respectively; error bars indicate SEM. factor forkhead box P3 (Foxp3) (Beier et al., 2012; Tao et al., 2007).”
Autism and Increased Paternal Age Related Changes in Global Levels of Gene Expression Regulation (2011, background): “Interestingly, HDAC inhibitors are known to affect immune, endocrine, and neurological systems, thus giving added support to the idea that globally targeting gene expression regulation can affect multiple systems [14,39,40,41].”
FOXP3+ regulatory T cells in the human immune system (2010, background): “In addition, as stable FOXP3 expression is a prerequisite for the suppressive function of T Reg cells, functional stability of infused FOXP3 + T Reg cells could be maintained or even enhanced by FOXP3 gene histone deacetylation or promotion of the acetylation of FOXP3 protein itself by inhibi”
T cell metabolism drives immunity (2015, background): “The actions of the transcription factor FoxP3 in directing T reg cell development are controlled through opposing activities of the HATs p300 and TIP60, and the HDAC Sirtuin1 (Sirt1; Li et al., 2007; Tao et al., 2007; van Loosdregt et al., 2010; Beier et al., 2011).”
Immunoregulatory Functions of mTOR Inhibition (2009, background): “This model of FOXP3 induction might explain the recent observation that a combination of histone deacetylase inhibition and rapamycin increases the number of FOXP3 + T Reg cells in vivo”
Regulation of Inflammation by Short Chain Fatty Acids (2011, background): “HDAC inhibitors enhance the production and suppressive function of regulatory T cells [77].”
Ischemia and reperfusion—from mechanism to translation (2011, background): “Indeed, pharmacological inhibitors of histone/protein deacetylases are effective in treating experimentally induced inflammatory bowel disease and in improving cardiac and islet graft survival in mouse transplantation models through increasing T reg cell numbers and functio”
The microbial metabolites, short chain fatty acids, regulate colonic Treg cell homeostasis (2013, background): “The HDAC inhibitor trichostatin-A (TSA) increases Treg gene expression and suppressive capacity (19); and HDAC6 and 9 down-regulate nTreg function (20).”