Vascular complications of diabetes: mechanisms of injury and protective factors
By C. Rask-Madsen, G. King. Cell Metabolism, 2013
788 citations recorded by the source corpus.
Summary In patients with diabetes, atherosclerosis is the main reason for impaired life expectancy, and diabetic nephropathy and retinopathy are the largest contributors to end-stage renal disease and blindness, respectively. An improved therapeutic approach to combat diabetic vascular complications might include blocking mechanisms of injury as well as promoting protective or regenerating factors, for example by enhancing the action of insulin-regulated genes in endothelial cells, promoting gene programs leading to induction of antioxidant or anti-inflammatory factors, or improving the sensitivity to vascular cell survival factors. Such strategies could help prevent complications despite suboptimal metabolic control.
Subfields: Clinical Biochemistry, Nephrology, Ophthalmology
View Paper: https://www.semanticscholar.org/paper/3be9df3ca209b2f7e0351b95e0fcf6b598382592
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Citations in the corpus
- Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications (2020, background): “The accelerated apoptosis of retinal capillary cells can be observed before the discovery of any histopathological changes in this diabetes complication [165, 166].”
- The PI3K/AKT pathway in obesity and type 2 diabetes (2018, background): “caemia, along with various comorbidities, such as cardiovascular disease, obesity, microangiopathy and renal failure [3].”
- Diabetic retinopathy: current understanding, mechanisms, and treatment strategies. (2017, background): “While considerable research effort has been directed toward identifying pathogenic pathways contributing to initiation and progression of DR, a growing paradigm is the importance of endogenous mechanisms that protect against DR (109, 110).”