Nitric oxide synthases: regulation and function.

By U. Förstermann, W. Sessa. European Heart Journal, 2012

4,137 citations recorded by the source corpus.

Subfields: Biochemistry, Cardiology and Cardiovascular Medicine, Physiology

View Paper: https://www.semanticscholar.org/paper/852e33e338fdae37909b14291cf1f58c0bcd4fac

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. C. Szabó
2. Guido Kroemer
3. D. Granger
4. P. Kvietys
5. Guy C. Brown
6. Chris E. Cooper

In Cardiology and Cardiovascular Medicine

1. C. Szabó
2. D. Granger
3. P. Kvietys

In Physiology

1. L. Galluzzi
2. Guido Kroemer
3. D. Granger
4. L. Liaudet
5. P. Kvietys
6. V. Schirrmacher
7. Rafael Radi

Citations in the corpus

• The role of oxidative stress during inflammatory processes (2013, background): “Oxidized PUFAs also form various cytotoxic aldehydes such as malondialdehyde and 4-hydroxynonenal (Devasagayam et al., 2003).”
• PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism (2020, background): “These isoforms utilize l-arginine and oxygen as substrates in almost all mammalian cells [103].”
• LOX-1, OxLDL, and Atherosclerosis (2013, background): “In disease conditions, ECs exhibit a reduced NO bioavailability, due to an increased degradation of NO in response to an enhanced oxidative stress [26].”
• Inducible Nitric Oxide Synthase: Regulation, Structure, and Inhibition (2019, background): “All NOS enzymes have a catalytically inactive zinc at the dimer interface.(10) One zinc atom per dimeric pair forms a zinc‐tetrathiolate cluster with each monomer donating two cysteine residues in a ‐CXXXXC‐ amino acid arrangement.”
• A review of soil NO transformation: associated processes and possible physiological significance on organisms (2015, background): “1021 Enzymatic NO synthesis by NOS appears to be much more important than 1022 non-enzymatic production (Zhou and Zhu, 2009; Chen et al., 2010; 1023 Forstermann and Sessa, 2012).”
• Chronic Inflammation and Cytokines in the Tumor Microenvironment (2014, background): “Different NOS isoforms are produced depending on cell type: inducibleNOS (iNOS) in phagocytic cells and constitutive in endothelial and neuronal (eNOS and nNOS) cells [108].”
• Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation (2012, background): “Based on our knowledge of the functional role of these amino acids in the regulation of eNOS (11, 12), the responses induced by H2S are highly consistent with the stimulation of the catalytic activity of eNOS.”
• Decoding cell death signals in liver inflammation. (2013, background): “However, whereas the endothelial NOS (eNOS) is constitutively active and mainly mediates the beneficial effects of NO on vasculature, its inducible counterpart (iNOS) is upregulated in response to stress, catalyzing intense (and hence potentially dangerous) waves of NO production [69].”
• Reperfusion injury and reactive oxygen species: The evolution of a concept (2015, background): “Finally, while iNOS is primarily induced in immune cells, such as macrophages, its expression can be increased in diverse cell populations and tissues [396,398].”