TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

By T. Chendrimada, Richard I. Gregory, Easwari Kumaraswamy, Jessica A. Norman, Neil Cooch, K. Nishikura, R. Shiekhattar. Nature, 2005

2,229 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/60dbcdf88ef4b73eb744a537113f07beea3d537c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

MicroRNA: Biogenesis, Function and Role in Cancer (2010, methodology): “Two studies performed by Haase et al. 2005 and Chendrimada et al. 2005 are in conflict [127].”
MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. (2008, methodology): “We thank Oded Meyuhas and Ramin Shiekhattar for materials, Lisa Frankel for comments on the manuscript, and Susanne Smed and Lis Schutt Nielsen for technical assistance.”
Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis. (2025, positive): “.4833 miR-10a miR-10b miR-21 miR-27a miR-155 miR-373 MDA231 Exosomes_72h 15 10 5 0 MDA231 Exosomes_24h 0 5 10 15 r=0.5087 E G miR-10a miR-10b miR-21 miR-27a miR-155 miR-373 64 32 16 8 4 2 1 0.5 24h 72h * * * 32 16 8 4 2 1 0.5 24h 72h * * * 16 8 4 2 1 0.5 24h 72h * * * 32 16 8 4 2 1 0.5 24h 72h * * *”
MicroRNAs in development and disease. (2011, background): “Some of the known proteins that form RISC include the RNA-specific endonuclease Dicer, which is involved in the processing of premiRNA into the mature form (259); the argonaute (Ago) protein, which has four isoforms, of which only Ago2, also known as “slicer,” has the capacity to cleave the target m”
TRBP, a regulator of cellular PKR and HIV‐1 virus expression, interacts with Dicer and functions in RNA silencing (2005, background): “After the submission of this work, another work describing the TRBP–Dicer partnership has been reported (Chendrimada et al, 2005).”
Mechanisms of microRNA‐mediated gene regulation (2007, background): “[ 54 ,56], but the possibility that these proteins have roles in subsequent steps in the pathway (e.g.”
Molecular mechanisms of RNA interference (2013, positive): “Resembling beads on a string, this domain architecture suggests that the protein may be involved in a dsRNA handoff between Dicer and Argonaute (92), but detailed mechanistic evidence is scarce.”
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. (2005, positive): “recently been proposed to load RISC containing Ago2 ( Chendrimada et al., 2005 ).”