Coronavirus Pathogenesis
By S. Weiss, J. Leibowitz. Advances in Virus Research, 2011
762 citations recorded by the source corpus.
Coronaviruses infect many species of animals including humans, causing acute and chronic diseases. This review focuses primarily on the pathogenesis of murine coronavirus mouse hepatitis virus (MHV) and severe acute respiratory coronavirus (SARS-CoV). MHV is a collection of strains, which provide models systems for the study of viral tropism and pathogenesis in several organs systems, including the central nervous system, the liver, and the lung, and has been cited as providing one of the few animal models for the study of chronic demyelinating diseases such as multiple sclerosis. SARS-CoV emerged in the human population in China in 2002, causing a worldwide epidemic with severe morbidity and high mortality rates, particularly in older individuals. We review the pathogenesis of both viruses and the several reverse genetics systems that made much of these studies possible. We also review the functions of coronavirus proteins, structural, enzymatic, and accessory, with an emphasis on roles in pathogenesis. Structural proteins in addition to their roles in virion structure and morphogenesis also contribute significantly to viral spread in vivo and in antagonizing host cell responses. Nonstructural proteins include the small accessory proteins that are not at all conserved between MHV and SARS-CoV and the 16 conserved proteins encoded in the replicase locus, many of which have enzymatic activities in RNA metabolism or protein processing in addition to functions in antagonizing host response.
Subfields: Animal Science and Zoology, Infectious Diseases
View Paper: https://www.semanticscholar.org/paper/c5a4401711103689cd391cc9e8b666b787c80aaa
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In Infectious Diseases
Citations in the corpus
- Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province (2020, neutral): “CoV, as an enveloped RNA virus that is ubiquitous in humans, other mammals, and birds, can cause respiratory, digestive, liver, and nervous system disorders.([5,6]) To date, six CoVs have been known to cause human infection.”
- The outbreak of COVID-19 coronavirus and its impact on global mental health (2020, background): “Complications included acute respiratory distress syndrome, acute cardiac injury and secondary bacterial infection (Huang et al., 2020; Su et al., 2016; Weiss & Leibowitz, 2011).”
- Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): An Update (2020, background): “Other tests that may assist in the diagnosis may include the flowcytometry analysis for CD4+ and CD8+ T cell counts, chest radiography (pneumonia), complete blood picture (to demonstrate lymphopenia), and serum biochemistry (serum protein and others) [9-10,13-14,41,43-44].”
- Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study (2020, background): “Coronaviruses are enveloped RNA viruses that could affect birds, humans, and other mammals, leading to respiratory, digestive, hepatic, and nervous system disorders.([4,5]) Among the six coronaviruses known to infect humans, two of them can cause ARDS, which are the severe acute respiratory syndrome”