Mechanisms of SARS-CoV-2 Transmission and Pathogenesis

By Andrew G. Harrison, Tao Lin, Penghua Wang. Trends in immunology, 2020

1,000 citations recorded by the source corpus.

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) marks the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 is highly transmissible with a broad tissue tropism that is likely perpetuating the pandemic. However, important questions remain regarding its transmissibility and pathogenesis. In this review, we summarize current SARS-CoV-2 research, with an emphasis on transmission, tissue tropism, viral pathogenesis, and immune antagonism. We further present advances in animal models that are important for understanding the pathogenesis of SARS-CoV-2, vaccine development, and therapeutic testing. When necessary, comparisons are made from studies with SARS to provide further perspectives on coronavirus infectious disease 2019 (COVID-19), as well as draw inferences for future investigations.

Subfields: Infectious Diseases, Neurology

View Paper: https://www.semanticscholar.org/paper/25a57224d1ed52410791e3243039b7de2dd5ef86

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Citations in the corpus

• Early computational detection of potential high-risk SARS-CoV-2 variants (2021, background): “The success of a viral variant in the global population is driven by more than these properties, but the S protein – the only SARS-CoV-2 protein considered in this study – primarily mediates host cell entry through ACE2 binding and serves as the main target of neutralising antibodies [26].”