Natural regulatory T cells control the development of atherosclerosis in mice

By H. Ait-Oufella, B. Salomon, Stephane Potteaux, A. Robertson, P. Gourdy, J. Zoll, R. Merval, B. Esposito, J. Cohen, S. Fisson and 5 more. Nature Medicine, 2006

1,165 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/608589a98c66d161f34c7abdbecd203746221b06

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Peter Libby
2. P. Ridker
3. G. Hansson
4. V. Z. Rocha
5. A. Lichtman
6. Klaus Ley
7. D. Wolf
8. A. Hermansson

Citations in the corpus

• Obesity, inflammation, and atherosclerosis (2009, background): “Transfer of T REG cells to atherosclerosis-susceptible mice reduces plaque burden, whereas depletion of these cells results in increased disease”
• Immunity and Inflammation in atherosclerosis (2019, background): “head box P3) and the high-affinity IL-2 receptor CD25 protect mice from atherosclerosis.(68,69) T regs exert their atheroprotective properties by secreting the anti-inflammatory cytokine IL-10,(70) plaque-stabilizing TGF (transforming growth factor)-β,(71) and”
• Progress and challenges in translating the biology of atherosclerosis (2011, background): “Regulatory T (T reg ) cells produce anti-inflammatory signals that tend to counteract T H 1-cell production of IFN-g — a cytokine that has long been implicated in atherogenesi”
• The immune system in atherosclerosis (2011, background): “Reconstitution of atherosclerotic mice with bone marrow deficient in CD80-CD86 or CD28 leads to more diseas”
• The immune response in atherosclerosis: a double-edged sword (2006, background): “A recent study supports this idea by showing that the transfer of natural CD4 + CD25 + regulatory T (T Reg ) cells reduces atherosclerosis, whereas depletion of CD25 + cells increases disease in Apoe −/− mic”
• History of Discovery: Inflammation in Atherosclerosis (2012, background): “Thus, the balance between T-cell subsets may influence the formation and character of lesions.(42,43) B cells also populate plaques.”
• Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans (2013, result): “In support of this notion, transfer of isolated CD4+CD25+ cells containing natural Treg cells reduced atherosclerosis and counteracted the proatherosclerotic effect of Treg cell deficiency (Ait-Oufella et al., 2006).”