Immunity and Inflammation in atherosclerosis
By D. Wolf, Klaus Ley. Circulation Research, 2019
1,367 citations recorded by the source corpus.
There is now overwhelming experimental and clinical evidence that atherosclerosis is a chronic inflammatory disease. Lessons from genome-wide association studies, advanced in vivo imaging techniques, transgenic lineage tracing mice, and clinical interventional studies have shown that both innate and adaptive immune mechanisms can accelerate or curb atherosclerosis. Here, we summarize and discuss the pathogenesis of atherosclerosis with a focus on adaptive immunity. We discuss some limitations of animal models and the need for models that are tailored to better translate to human atherosclerosis and ultimately progress in prevention and treatment.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/937fd8d962060aaf73f9f8ab090554b21cf8d4a5
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In Immunology
Citations in the corpus
- Pattern recognition receptors in health and diseases (2021, background): “It has been reported that TLRs are extensively and deeply involved in the process of atherosclerosis.(400,401) TLR7 has been identified as a good prognosis marker for patients with severe atherosclerosis.”
- Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel (2020, background): “been identified, linking adaptive immune responses to the vascular retention of LDL (Figure 3).(147) Interferon-gamma (IFNc)-secreting CD4þ Th1 cells promote”
- Inflammation and atherosclerosis: signaling pathways and therapeutic intervention (2022, background): “Genome-wide association combined with clonal lineage tracing and clinical trials have identified that the mechanisms of innate and adaptive immunes can promote or quell atherosclerosis.(8) Much evidence suggests that potential major antigens involved in atherosclerosis include neoepitopes generated ”