Mast-cell infiltration of airway smooth muscle in asthma.

By C. Brightling, P. Bradding, F. Symon, S. Holgate, A. Wardlaw, I. Pavord. New England Journal of Medicine, 2002

1,300 citations recorded by the source corpus.

Subfields: Immunology, Physiology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/602c1a4e19c3dac37d79aeabd8385a47f84ae3ae

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. S. Galli
2. S. Bischoff
3. M. Tsai
4. H. Hammad
5. B. Lambrecht
6. S. Holgate
7. P. Barnes
8. Marc E. Rothenberg

In Physiology

1. S. Galli
2. M. Tsai
3. H. Hammad
4. B. Lambrecht
5. S. Holgate
6. S. Bischoff
7. P. Barnes
8. Marc E. Rothenberg

In Rheumatology

1. S. Bischoff
2. Marc E. Rothenberg
3. S. Galli

Citations in the corpus

• Immunology of asthma and chronic obstructive pulmonary disease (2008, background): “The presence of mast cells in the airway smooth muscle has been linked to airway hyper-responsiveness in asthm”
• The role of mast cells in allergic inflammation. (2012, result): “Signs of mast cell activation in allergic asthma have been indicated by others.(40) However, in that study we could not observe any differences between allergic and nonallergic asthmatics.”
• The development of allergic inflammation (2008, background): “In patients with asthma, mast cells can appear in increased numbers in the smooth muscle of the airway ( Figs 5 and 6 ), placing this potent source of mediators that can influence smooth muscle function in intimate proximity to this crucial target-cell populatio”
• The role of the mast cell in the pathophysiology of asthma. (2006, methodology): “Reproduced with permission.(9) C, IL-4(1) mast cells (arrows) within an ASM bundle.”
• Eosinophils: Biological Properties and Role in Health and Disease (2008, background): “Further evidence casting doubt on a role for eosinophils in AHR comes from studies of eosinophilic bronchitis (Brightling et al. 2002, 2003).”
• Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data (2007, background): “The lipid mediator evokes airway hypersensitivity and chemotaxis of T cells, basophils and eosinophils through interaction with two receptors, the prostaglandin D 2 receptor (PTGDR) on granulocytes and smooth muscle cells, and CRTH2 (chemoattractant receptor-homologous molecule expressed on T H 2 c”
• Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma (2008, background): “Particularly in human asthma, the degranulation and production of T H 2-cell-associated cytokines by mast cells that occurs in the smooth-muscle layer surrounding the airway wall are important in causing this bronchial hyper-reactivit”