The role of the mast cell in the pathophysiology of asthma.

By P. Bradding, A. Walls, S. Holgate. Journal of Allergy and Clinical Immunology, 2006

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Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells (2007, background): “These fi ndings suggested to us that TSLP may directly activate eff ector cells of the innate immune system like MCs, which are known to play an important role in the pathogenesis of atopic diseases (13, 14).”
Treatment strategies for allergy and asthma (2008, background): “After inhalation, both drugs inhibit the allergen-induced early- and late-phase responses in the upper and lower airways and conjunctiva, where mucosal mast cells are crucially involved in the allergic respons”
The development of allergic inflammation (2008, background): “Certain mast-cell-derived products can also influence the biology of structural cells, including vascular endothelial cells, epithelial cells, fibroblasts, smooth muscle cells and nerve cell”