The development of allergic inflammation
By S. Galli, M. Tsai, A. Piliponsky. Nature, 2008
1,797 citations recorded by the source corpus.
Allergic disorders, such as anaphylaxis, hay fever, eczema and asthma, now afflict roughly 25% of people in the developed world. In allergic subjects, persistent or repetitive exposure to allergens, which typically are intrinsically innocuous substances common in the environment, results in chronic allergic inflammation. This in turn produces long-term changes in the structure of the affected organs and substantial abnormalities in their function. It is therefore important to understand the characteristics and consequences of acute and chronic allergic inflammation, and in particular to explore how mast cells can contribute to several features of this maladaptive pattern of immunological reactivity.
Subfields: Immunology, Immunology and Allergy, Physiology
View Paper: https://www.semanticscholar.org/paper/1995ff44a0440dea7cc9168aa28351fb1f8e7a46
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In Immunology
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Citations in the corpus
- Metabolic Regulation of Immune Responses (2014, background): “In addition, their pathogenic activation contributes to allergies and anaphylaxis (36).”
- New developments in mast cell biology (2008, background): “Another goal is to understand how the mast cell lineage can accomplish so many distinct functions depending on the setting, either promoting or limiting innate or adaptive immune response”
- Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients (2012, methodology): “Comparison of sample matrices—Blood was obtained by means of venipuncture from 10 healthy subjects using 4 typical clinical specimen tubes for each donor: (1) serum, (2) plasma anticoagulated with EDTA, (3) plasma anticoagulated with sodium citrate, and (4) plasma anticoagulated with heparin.”