Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch

By Zhengmei Mao, G. Roman, Lin Zong, Ronald L. Davis. 2003

148 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Yi Zhong
2. Qian Li
3. Ronald L. Davis
4. Liyuan Wang
5. Xuchen Zhang
6. Bohan Zhao
7. Wantong Hu
8. Lianzhang Wang

In Molecular Biology

1. Qian Li
2. Yi Zhong
3. Xuchen Zhang
4. Liyuan Wang
5. Ronald L. Davis
6. Lianzhang Wang
7. Zhong-Jian Liu
8. Yichun Shuai

Citations in the corpus

• Genetic dissection of mutual interference between two consecutive learning tasks in Drosophila (2022, methodology): “Transgene Induction In this study, two inducible systems, GeneSwitch (Mao et al., 2004) and TARGET (McGuire et al., 2003), were used for transgene expression.”
• D1 Dopamine Receptor dDA1 Is Required in the Mushroom Body Neurons for Aversive and Appetitive Learning in Drosophila (2007, background): “…observations that synaptic output of dopaminergic neurons is necessary during training (Schwaerzel et al., 2003), and the learning phenotype of rut mutants is rescued by the restricted expression of rut-AC, a potential dDA1 effector, in the adult MB (McGuire et al., 2003; Mao et al., 2004).”
• Dynamics of learning-related cAMP signaling and stimulus integration in the Drosophila olfactory pathway. (2009, unknown): “rut function is required only in the adult mushroom body for complete phenotypic rescue in aversive conditioning tests (Zars et al., 2000; McGuire et al., 2003; Mao et al., 2004).”
• Cdc42-Dependent Forgetting Regulates Repetition Effect in Prolonging Memory Retention. (2016, methodology): “, 2011), an MB-specific driver, MB-GeneSwitch (MB-GS) Gal4 (Mao et al., 2004), was used to target expression of Cdc42 mutants.”
• Mg2+ Block of Drosophila (2012, unknown): “LTM was normal in both lines in the absence of RU486.”
• Sequential use of mushroom body neuron subsets during drosophila odor memory processing. (2007, unknown): “Experiments conducted with learning and memory defective mutant flies have led to the prevailing model where MB neurons associate the odor CS with 4 the shock, or sugar US, using potential coincidence detecting molecules like RUT adenylyl cyclase (Zars et al., 2000; McGuire et al., 2003; Mao et al.,”
• Drosophila α/β Mushroom Body Neurons Form a Branch-Specific, Long-Term Cellular Memory Trace after Spaced Olfactory Conditioning (2006, unknown): “…transgene specifically in the MB of adult flies rescues the memory impairment of rutabaga mutants that is observed immediately after olfactory conditioning (McGuire et al., 2003; Mao et al., 2004), indicating that normal rutabaga function in the MBs is required for the expression of early memory.”
• Inability to activate Rac1-dependent forgetting contributes to behavioral inflexibility in mutants of multiple autism-risk genes (2016, background): “After acute knockdown of Fmr1, Ube3a, Nrx-1, and Tsc1 expression in the mushroom body (59), normal learning ability, significant reversal-learning defects, and unforgettable old memory were observed (Fig.”
• Active Protection: Learning-Activated Raf/MAPK Activity Protects Labile Memory from Rac1-Independent Forgetting. (2018, unknown): “This was achieved by feeding the flies RU486, which activates an inducible MB-specific driver (MB-GS) (Mao et al., 2004) (Figure S1D).”
• Short and Long-term memory in Drosophila require cAMP signaling in distinct neuron types (2009, background): “In the case of the RUTABAGA adenylyl cyclase, expression is elevated in MBs [22], and transgenic expression in MBs of a rutabaga+ cDNA is sufficient to rescue the learning defect of the rutabaga mutant [23–25].”
• Genetic dissection of active forgetting in labile and consolidated memories in Drosophila (2019, methodology): “Consistent with our previous finding (4), flies expressing constitutively active Cdc42 (MB-GS/UAS-Cdc42-CA, RU486+) had reduced ARM performance at 9 h after a 1-session training when compared with control flies (MB-GS/+, RU486+).”
• Olfactory memory formation in Drosophila: from molecular to systems neuroscience. (2005, background): “Rut mutant flies carrying a transgene that provided Gene-Switch activity in the MB neurons along with UAS-rut+ were fed on RU486 as adults, which rescued the rut learning impairment (Mao et al. 2004).”