Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.

By Benjamin P. Lewis, C. Burge, David P. Bartel. 2005

12,333 citations recorded by the source corpus.

Subfields: Cancer Research, Plant Science

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Citations in the corpus

TarBase: A comprehensive database of experimentally supported animal microRNA targets. (2005, background): “We must emphasize, however, that machine-learning methods for target prediction are not necessarily superior to approaches that do not employ training sets (Lewis et al. 2003, 2005; Krek al.”
Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes (2007, background): “Although perfect pairing at the seed region is important for identifying miRNA-binding site”
Control of translation and mRNA degradation by miRNAs and siRNAs. (2006, background): “An additional example in which a miRNA can target mRNAs for decay comes from the analysis of mRNA decay stimulated by an AU-rich 3 UTR regulatory sequence (ARE).”
miRSystem: An Integrated System for Characterizing Enriched Functions and Pathways of MicroRNA Targets (2012, methodology): “Seven algorithms predicting miRNA targets, DIANA-microT [13] [14], miRanda [9] [22] [23], mirBridge [15], PicTar [16], PITA [18] , rna22 [17] , and TargetScan [10] [11] [12], and two experimentally validated databases, TarBase [24] and miRecords [25], of miRNA target genes were included.”
Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals (2005, result): “The results thus provide an unbiased assessment of the relative importance of miRNA-based regulation in the human genome, consistent with recent independent studie”
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. (2007, background): “tive, but specificity remains a problem in efficiently identifying targets (Didiano and Hobert, 2006; Lewis et al., 2005; Rajewsky, 2006).”
miR-19 is a key oncogenic component of mir-17-92. (2009, background): “1B; Lewis et al. 2003, 2005; Farh et al. 2005; Grimson et al. 2007).”
Inositol phosphatase SHIP1 is a primary target of miR-155 (2009, methodology): “SHIP1 3 UTR sequences from human, mouse, rat and dog were obtained and aligned with each other and with the miR-155 seed region using TargetScan (24).”
MicroRNAs are Transported in Plasma and Delivered to Recipient Cells by High-Density Lipoproteins (2011, background): “1) identified mRNAs that are conserved putative targets of the 22 differentially abundant miRNAs on familial hypercholesterolemia HDL (refs&nbs”