The human hippocampus and spatial and episodic memory.

By Neil Burgess, Eleanor A. Maguire, John O'Keefe. Neuron, 2002

2,409 citations recorded by the source corpus.

Finding one's way around an environment and remembering the events that occur within it are crucial cognitive abilities that have been linked to the hippocampus and medial temporal lobes. Our review of neuropsychological, behavioral, and neuroimaging studies of human hippocampal involvement in spatial memory concentrates on three important concepts in this field: spatial frameworks, dimensionality, and orientation and self-motion. We also compare variation in hippocampal structure and function across and within species. We discuss how its spatial role relates to its accepted role in episodic memory. Five related studies use virtual reality to examine these two types of memory in ecologically valid situations. While processing of spatial scenes involves the parahippocampus, the right hippocampus appears particularly involved in memory for locations within an environment, with the left hippocampus more involved in context-dependent episodic or autobiographical memory.

Subfields: Cell Biology, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/5f8e64cc066886a99cc8e30e68d1b29d8bb1961d

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Citations in the corpus

The medial temporal lobe and memory (2007, background): “, 2005) and encoding the locations of objects in complex virtual environments (Burgess et al., 2002; Maguire et al., 1998).”
Cellular networks underlying human spatial navigation (2003, result): “Our dissociation of parahippocampal and hippocampal function, together with the data discussed above, provide cellular evidence for an emerging mode”
Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion. (2012, neutral): “The hippocampus plays a crucial role in episodic memory (Scoville and Milner, 1957; Burgess et al., 2002; Squire et al., 2004).”
Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. (2009, background): “The hippocampus (HPC) is crucial for the formation of some types of declarative memories during the mnemonic process in humans (Burgess et al., 2002; Scoville and Milner, 1957; Squire et al., 2004).”
Thoughts, behaviour, and brain dynamics during navigation in the real world (2006, neutral): “The hippocampus has long been associated with navigation in both animals and humans (Burgess et al., 2002; O’Keefe and Nadel, 1978).”
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. (2007, neutral): “The hippocampus plays key roles in learning and memory (Burgess et al., 2002; Frankland and Bontempi, 2005; Morris et al., 1982; O’Keefe et al., 1975) and is a prime target of Alzheimer’s disease (AD), which causes progressive memory impairments (Blennow et al., 2006).”
Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus (2004, background): “In the mammalian hippocampus, a region important for spatial and episodic memor”
Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline (2016, positive): “Specifically, we discuss recent work on the role of cholinergic signaling in spatial memory, which heavily engages the hippocampus, and in emotionally salient memories, with a focus on studies in the amygdala (Burgess et al., 2002; Janak and Tye, 2015).”
Source monitoring 15 years later: What have we learned from fMRI about the neural mechanisms of source memory? (2009, background): “…conjunction with entorhinal cortex [Lipton & Eichenbaum, 2008], or midbrain structures [Shohamy & Wagner, 2008]) whenever information is bound, associated, or integrated across time or space (see Bird & Burgess, 2008; Burgess et al., 2002; Nadel & Hardt, 2004, for reviews and related discussions).”
Multimodal Feature Integration in the Angular Gyrus during Episodic and Semantic Retrieval (2016, background): “Moreover, whereas the hippocampus may integrate elements of an episodic memory such as space and time (Burgess et al., 2002; Eichenbaum, 2014), AnG may integrate sensory elements of multimodal memories into a complete and vivid recollection.”
The cognitive neuroscience of remote episodic, semantic and spatial memory. (2006, background): “Although it is not fully developed, the treatment of human memory hypothesized by the CM theory suggests that episodic, but not semantic, memory is mediated by the hippocampus, because spatial context is an integral part of episodes, whereas semantic memory is context-free [13,14].”
Hippocampal Contributions to Model-Based Planning and Spatial Memory (2019, neutral): “With those caveats, we expected boundary-based memory, and spatial relations generally, to be more strongly associated with the right hippocampus (Burgess et al., 2002).”
Differential control of learning and anxiety along the dorso-ventral axis of the dentate gyrus (2013, background): “Lesion studies in both humans and animals, have demonstrated an essential role for the hippocampus in episodicmemory formation (Burgess et al., 2002).”