Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus

By Christoph Schmidt-Hieber, Peter Jonas, J. Bischofberger. 2004

1,345 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience, Neuroscience

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Citations in the corpus

Adult neurogenesis in brain repair: cellular plasticity vs. cellular replacement (2014, background): “Indeed it has been shown that newly generated neurons, as compared to mature granule cells, exhibit a lower threshold for induction of LTP (Schmidt-Hieber et al., 2004).”
Dynamics of hippocampal neurogenesis in adult humans (2013, methodology): “The accuracy of individual datings is approximately ±1.5 years (Spalding et al., 2005b), but higher accuracy is reached by integrating data from many independent measurements.”
Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion. (2012, positive): “Third, we confirmed by X-ray irradiation that adultborn DGGCs are crucial for efficient acquisition of the contextual discrimination power in normal mice (Scobie et al., 2009; Tronel et al., 2012; Sahay et al., 2011).”
Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways (2006, background): “functionally integrated into the existing neuronal network (van Praag et al., 2002; Overstreet et al., 2004; Schmidt-Hieber et al., 2004).”
Neurogenesis in the striatum of the adult human brain. (2014, neutral): “The generation of new neurons in the adult brain serves to maintain a pool of neurons with unique properties, present for a limited time after their birth, which enable specific types of neural processing (Ge et al., 2007; Schmidt-Hieber et al., 2004).”
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer’s Disease (2009, positive): “624 Cell Stem Cell 5, 624–633, December 4, 2009 a2009 Elsevier In possible roles in experience-induced plasticity (Ge et al., 2007; Schmidt-Hieber et al., 2004).”
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. (2007, positive): “Previous studies have established that the membrane resistance of new neurons decreases along their maturation (Esposito et al., 2005;Schmidt-Hieber et al., 2004).”
Adult neurogenesis: from precursors to network and physiology. (2005, background): “Recently, PSA-NCAM expressing cells have been shown to differ from mature neurons in their passive (input resistance) and active membrane properties (such as calcium spikes that boost fast sodium action potentials) and in their enhanced ability to develop LTP (490).”
Spatial firing correlates of physiologically distinct cell types of the rat dentate gyrus (2012, background): “Newborn granule cells are more excitable than older granule cells and are more likely to undergo long-term potentiation (Wang et al., 2000; Schmidt-Hieber et al., 2004; Ge et al., 2006).”