Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion.

By T. Nakashiba, Jesse D. Cushman, K. Pelkey, S. Renaudineau, D. Buhl, T. McHugh, Vanessa Rodriguez Barrera, R. Chittajallu, Keisuke S. Iwamoto, C. McBain and 2 more. 2012

821 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Developmental Neuroscience

Citations in the corpus

Generalization Through the Recurrent Interaction of Episodic Memories (2012, background): “…inputs from the ERC (Kesner & Hopkins, 2006; J. K. Leutgeb, Leutgeb, Moser, & Moser, 2007; S. Leutgeb, Leutgeb, Treves, Moser, & Moser, 2004; Nakashiba et al., 2012; Vazdarjanova & Guzowski, 2004) and that this function has important behavioral consequences (Clelland et al., 2009; Deng et…”
Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “Adult-born granule cells have also been implicated in contextual discrimination (Sahay et al., 2011; Nakashiba et al., 2012; Danielson et al., 2016), a result that parallels recent findings that suggest that adult neurogenesis facilitates pattern decorrelation in the olfactory bulb (Li et al.”
Dynamics of hippocampal neurogenesis in adult humans (2013, background): “…that adult-born neurons integrate long term in rodents, whether they last for the remainder of the animal’s life has not been studied, although the available data are compatible with a preferential loss of adult-born neurons (Imayoshi et al., 2008; Kempermann et al., 2003; Ninkovic et al., 2007).”
The current state of the neurogenic theory of depression and anxiety. (2015, background): “AHN is sufficient to impair pattern separation and cognitive flexibility – cognitive functions relevant to depression and anxiety [32,44].”
Tracking the Flow of Hippocampal Computation: Pattern Separation, Pattern Completion, and Attractor Dynamics (2015, background): “A particularly critical question concerns the role of adult neurogenesis in the functions of the DG (Nakashiba et al., 2012; Frankland, Kohler, & Josselyn, 2013; Akers et al., 2014; Kesner et al., 2014).”
Physiological properties and behavioral correlates of hippocampal granule cells and mossy cells (2017, neutral): “In support of this hypothesis, damage to the dentate gyrus diminishes the animals’ ability to distinguish between similar environmental contexts, supporting its role in pattern separation (Gilbert et al., 2001; McHugh et al., 2007; Hunsaker et al., 2008; Kim and Lee, 2011; Nakashiba et al., 2012).”
Pattern separation in the hippocampus through the eyes of computational modeling (2017, methodology): “…experiments, pattern separation is typically measured by behavioral assessment (behavioral pattern separation [Santoro, 2013]): animals are asked to perform a different task depending on their interpretation of similar stimuli (Leutgeb et al., 2007; Kannangara et al., 2014; Nakashiba et al., 2012).”
The germinal matrices in the developing dentate gyrus are composed of neuronal progenitors at distinct differentiation stages (2013, background): “Pax6 Expression Marks the Boundary Between the Dentate Neuroepitheilum and the Cortical Hem We have been studying Pax6 function in the brain development (Osumi et al., 2008).”
Entorhinal Cortical Ocean Cells Encode Specific Contexts and Drive Context-Specific Fear Memory. (2015, neutral): “, 2004) and dynamics of adult-born young granule cells which compose just a few percent of the total DG-GCs (Clelland et al., 2009; Creer et al., 2010; Deng et al., 2010; Nakashiba et al., 2012; Sahay et al., 2011; Scobie et al., 2009).”
Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding (2016, positive): “, 2003); and, most recently, in behaviors requiring contextual discrimination, consistent with a role in pattern separation (Clelland et al., 2009; Kheirbek et al., 2012a; Nakashiba et al., 2012; Sahay et al., 2011a).”