Hippocampal Contributions to Model-Based Planning and Spatial Memory
By Oliver M. Vikbladh, Michael R. Meager, John A. King, Karen E. Blackmon, Orrin Devinsky, Daphna Shohamy, Neil Burgess, Nathaniel D. Daw. 2019
134 citations recorded by the source corpus.
Summary Little is known about the neural mechanisms that allow humans and animals to plan actions using knowledge of task contingencies. Emerging theories hypothesize that it involves the same hippocampal mechanisms that support self-localization and memory for locations. Yet, limited direct evidence supports the link between planning and the hippocampal place map. We addressed this by investigating model-based planning and place memory in healthy controls and epilepsy patients, treated using unilateral anterior temporal lobectomy with hippocampal resection. Both functions were impaired in the patient group. Specifically, the planning impairment was related to right hippocampal lesion size, controlling for overall lesion size. Furthermore, while planning and boundary-driven place memory co-varied in the control group, this relationship was attenuated in patients, consistent with both functions relying on the same structure in the healthy brain. These findings clarify both the neural mechanism of model-based planning and the scope of hippocampal contributions to behavior.
Subfields: Cell Biology, Cognitive Neuroscience, Developmental and Educational Psychology
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In Cognitive Neuroscience
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Citations in the corpus
- Towards Continual Reinforcement Learning: A Review and Perspectives (2020, background): “Additionally, there is strong evidence in the literature of hippocampal replay facilitating the model-based planning process for human RL (Mattar and Daw, 2018; Momennejad et al., 2018; Vikbladh et al., 2019; Momennejad, 2020).”