Direct isolation of human central nervous system stem cells.

By N. Uchida, D. Buck, Dongping He, Michael J. Reitsma, M. Masek, Thinh V. Phan, A. Tsukamoto, Fred H. Gage, Irving L. Weissman. Proceedings of the National Academy of Sciences of the United States of America, 2000

1,924 citations recorded by the source corpus.

Subfields: Cancer Research, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5f7b887700e0a442c258f238a73a06aa476da2f5

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Citations in the corpus

The biology of cancer stem cells. (2007, background): “He provided the scientific basis for cancer by correlating clinical outcomes with microscopic findings ( Virchow 1858).”
Stems cells and the pathways to aging and cancer. (2008, background): “Given that the cellular origin of brain tumors may arise directly from the progeny of CD133+ stem cells (Uchida et al., 2000), it will be important to determine if changes in the developmental potential of NSCs during ontogeny underlie the predisposition to the changing spectrum of brain tumors…”
Radial glia cells are candidate stem cells of ependymoma. (2005, background): “Neurosphere (hereon termed tumor sphere)-forming cells isolated from medulloblastoma and glioma express the neural stem cell marker CD133 and exhibit the ability to self-renew and differentiate along divergent neuronal lines (Hemmati et al., 2003; Ignatova et al., 2002; Singh et al., 2003; Uchida et”
An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells (2009, neutral): “Furthermore, the splicing patterns in FOX2-depleted human fetal neural stem cells (human central nervous system stem cells propagated as neurospheres, hCNS-SCns) were similar to FOX2-depleted HUE6-NP cell”
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. (2007, background): “CD133 is expressed by normal tissue-resident as well as hematopoietic stem cells (Peichev et al., 2000; Uchida et al., 2000; Yin et al., 1997).”
Directed differentiation of embryonic stem cells into motor neurons. (2002, background): “Studies of the neurogenic potential of progenitor cells have focused on three major classes of cells: neural progenitors derived from embryonic or adult nervous tissue (Alvarez-Buylla et al., 2001; Gage, 2000; Uchida et al., 2000), nonneural progenitor cells derived from other tissues and organs (Br”
Spherical Cancer Models in Tumor Biology (2015, background): “Initially, the quantification and characterization of such floating spherical aggregates had been developed for normal neural stem cells grown as neurospheres, in which a single cell is able to give rise to a sphere by clonal expansion [35,66].”