A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST).

By Kathleen M. Ward, A. Aletras, R. Balaban. Journal of magnetic resonance (San Diego, Calif. 1997 : Print), 2000

1,346 citations recorded by the source corpus.

Subfields: Biophysics, Materials Chemistry, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/5f7181184417123bae417f813507d6cc0f50c29b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biophysics

1. Jinyuan Zhou
2. G. Storm
3. P. V. Zijl

In Materials Chemistry

1. Peter C. M. van Zijl
2. N. Yadav
3. P. V. Zijl
4. Jiadi Xu
5. Wilfred Lam
6. Linda Knutsson
7. Greg J. Stanisz
8. Jinyuan Zhou

In Radiology, Nuclear Medicine and Imaging

1. Peter C. M. van Zijl
2. N. Yadav
3. P. V. Zijl
4. Jiadi Xu
5. Wilfred Lam
6. Linda Knutsson
7. Greg J. Stanisz
8. John A. Detre

Citations in the corpus

• Magnetic Resonance Imaging of Glutamate (2012, positive): “The CEST effect from amide and hydroxyl protons from different amino acids, proteins and other molecules 12,16,17 have previously been exploited to measure pH in vivo 18,19 , glycogen in the liver 20 , glycosaminoglycans in cartilage 21 , gene expression in vivo 22 , and myo-inositol in brain, 23…”
• Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI (2003, methodology): “assumed base-catalyzed exchange and used the pH values determined in vivo and postmortem by 31P spectroscopy to restrict the exchange-rate ratio, as defined by equation (2).”
• WAter Saturation Shift Referencing (WASSR) for chemical exchange saturation transfer experiments (2009, neutral): “[1]”
• Chemical Exchange Saturation Transfer (CEST): what is in a name and what isn’t? (2011, background): “A very elegant and more straightforward approach was suggested by Ward and Balaban (32), who used a ratiomeric approach for the PTR of two distinguishable protons with different pH dependence in the same molecule.”
• Magnetization Transfer Contrast and Chemical Exchange Saturation Transfer MRI. Features and Analysis of the Field-Dependent Saturation Spectrum (2017, background): “CEST MRI was named (Ward et al., 2000) to describe the transfer of such saturated protons from metabolites and contrast agents to water protons via the exchange of protons between molecules.”
• Nuclear Overhauser Enhancement (NOE) Imaging in the Human Brain at 7 T (2013, neutral): “While originally starting with classical continuous saturation (Goffeney et al., 2001; Ward et al., 2000) or rapid-repeat pulsed saturation (Zhou et al., 2003a) methods, it was only later realized that the CEST field has the opportunity to use selective excitation approaches (Friedman et al., 2010;…”
• Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release (2010, methodology): “derived imaging procedure which is based on the use of CEST agents containing one or more exchangeable proton pools (191,192).”