Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI

By Jinyuan Zhou, J. Payen, David A Wilson, R. Traystman, P. V. Zijl. Nature Medicine, 2003

1,183 citations recorded by the source corpus.

Subfields: Materials Chemistry, Radiology, Nuclear Medicine and Imaging, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/6824a88404f89bd83439f96ec4fa0626b32165dc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Materials Chemistry

1. Peter C. M. van Zijl
2. N. Yadav
3. P. V. Zijl
4. Jiadi Xu
5. Wilfred Lam
6. Linda Knutsson
7. Greg J. Stanisz
8. Jinyuan Zhou

In Radiology, Nuclear Medicine and Imaging

1. Peter C. M. van Zijl
2. N. Yadav
3. P. V. Zijl
4. Sean C. L. Deoni
5. Jiadi Xu
6. Wilfred Lam
7. Linda Knutsson
8. Greg J. Stanisz

Citations in the corpus

• Magnetization Transfer Contrast and Chemical Exchange Saturation Transfer MRI. Features and Analysis of the Field-Dependent Saturation Spectrum (2017, methodology): “…frequency of 3.5 ppm using so-called APT-weighted MRI, which allows the clear detection of malignant brain tumors (Jones et al., 2006; Salhotra et al., 2008; Wen et al., 2010; Zhou et al., 2008, 2003a) and even the separation of recurrent tumors from treatment necrosis effects (Zhou et al., 2011).”
• WAter Saturation Shift Referencing (WASSR) for chemical exchange saturation transfer experiments (2009, methodology): “For instance, CEST observation of solutes and particles in the millimolar to nanomolar range has been demonstrated both in vitro (3,6,14–17) and in vivo (10,18,19).”
• Nuclear Overhauser Enhancement (NOE) Imaging in the Human Brain at 7 T (2013, methodology): “However, the consistent increase in MTRasym (3.5 ppm) found in high grade tumors (Zhou et al., 2008) and its negligible change in radiation necrosis (Zhou et al., 2011) makes APT-weighted imaging a powerful clinical indicator of presence of new or recurrent tumors.”
• Chemical Exchange Saturation Transfer (CEST): what is in a name and what isn’t? (2011, methodology): “8a) or pulsed (25,33,69,70) selective off-resonance saturation of the exchangeable protons.”
• Magnetic Resonance Imaging of Glutamate (2012, neutral): “In the MCAO model, it is also well-established that the magnitude of pH decrease expected over a four hour period is ~0.5 units 18 .”
• The Development of Brain White Matter Microstructure (2018, background): “Chemical exchange saturation transfer (CEST) approaches including amide proton transfer (APT) imaging (Zhou et al., 2003) also offer contrast mechanisms based on interactions between macromolecular and water protons that may useful for assessing microstructural brain development.”