Function and regulation of CREB family transcription factors in the nervous system.

By B. E. Lonze, D. Ginty. Neuron, 2002

2,167 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5f3c0d4d83a037c448c0a37ef7cf7c37b93b1e04

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In Cellular and Molecular Neuroscience

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Citations in the corpus

MAP kinase and pain (2008, background): “Furthermore, the neurotrophin brain derived neurotrophic factor (BDNF), which is constitutively expressed by a subpopulation of sensory neurons, can be co-released with glutamate and SP following a specific pattern of activation of primary afferent fibers (Lever et al., 2001).”
Short and Long-term memory in Drosophila require cAMP signaling in distinct neuron types (2009, background): “Short-term plasticity generally involves modification of preexisting proteins, whereas long-term plasticity and memory involve recruitment of a cascade of new gene expression [4–6].”
The molecular and systems biology of memory. (2014, neutral): “That said, the role of CREB in models of explicit memory in vertebrates appears to be more complex than it is in implicit memory in invertebrates (Barco et al., 2002; Lonze and Ginty, 2002; Pittenger et al., 2002).”
Addiction: a disease of learning and memory. (2005, background): “Given a theory of addiction as a pathological usurpation of long-term memory, given the increasingly well-established role for CREB in several forms of long-term memory (87, 88), and given the ability of cocaine and amphetamine to activate CREB (88–90), there has been much interest in the possible r”
GABA-CREB signalling regulates maturation and survival of newly generated neurons in the adult hippocampus (2009, background): “This redundancy is clearly evident from the phenotype of single knock-out mice, which display only subtle defects in most brain tissues (Hummler et al., 1994; Lonze and Ginty, 2002).”
Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration. (2004, background): “…gene ex-1051 Riverside Drive pression required for the acquisition and storage of newNew York, New York 10032 memories, as evident in a variety of experimental sys-3 Laboratory of Molecular Genetics tems ranging from mollusks to mammals (Kandel, 2001;RIKEN Tsukuba Institute Lonze and Ginty, 2002).”
Regulation of gene expression and cocaine reward by CREB and ΔFosB (2003, background): “CREB is ubiquitously expressed and is activated through the cAMP pathway as well as several other second-messenger system”
The Biology of Regeneration Failure and Success After Spinal Cord Injury. (2018, background): “Indeed, this key intracellular signaling molecule has been shown to increase neuronal regeneration in a number of models (55, 71, 314, 315) through its effect on PKA (131, 239, 335), and by increasing growth factor receptor translocation from the cytoplasm to the cell membrane (263).”
Global and Local Architecture of the Mammalian microRNA–Transcription Factor Regulatory Network (2007, background): “Interestingly though, we can point out an example of one indirect FFL we discovered, where a brain-related TF, CREB (CREBATF) [39], partners with a miR that is known to be expressed in the brain, miR-125b [40].”
Alcoholism: a systems approach from molecular physiology to addictive behavior. (2009, background): “One of the substrates of PKA is the transcription factor cAMP response element-binding protein (CREB), which eventually results in increased transcription of genes containing cAMP response elements (CRE) in their promoter region (280).”
Rapid Consolidation to a radish and Protein Synthesis-Dependent Long-Term Memory after Single-Session Appetitive Olfactory Conditioning in Drosophila (2008, background): “…protein (CREB) is universally required for LTM, and it is widely believed that the requirement for new protein synthesis after training is, at least in part, a reflection of a need to translate transcripts from CREB-induced genes (Yin et al., 1994; Lonze and Ginty, 2002; Barco et al., 2003).”
Neurotrophins and their receptors: A convergence point for many signalling pathways (2003, background): “CREB has effects on the cell cycle, neurite outgrowth and synaptic plasticit”
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system (2003, background): “To test whether additional aspects of synaptic signaling are regulated by the activity state of the synapse, I examined the ability of NMDA receptors to activate CREB and ERK-MAPK—two prominent signal transduction cascades organized by the PSD and involved in synaptic plasticit”
The restless engram: consolidations never end. (2012, background): “That said, the role of CREB in models of explicit memory in vertebrates appears to be more complex than it is in implicit memory in invertebrates (Barco et al., 2002; Lonze and Ginty, 2002; Pittenger et al., 2002).”