Targeting the ubiquitin system in cancer therapy

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Ubiquitin-binding domains — from structures to functions (2009, background): “Several UBDs have now been linked to various human pathologies, including cancer and immune deficiencies, thus becoming interesting as putative targets for therap”
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6 (2013, methodology): “(d) HEK293 cells were co-transfected with vectors encoding AMBRA1 together with ULK1–Myc FL (full length) or its deletion mutants encoding the kinase and the proline-rich domains (1829–1,051), and the ULK1 carboxy-terminal domain (11-828).”
A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles (2011, background): “These results show that steady-state ubiquitylation of histones is altered by disruption of the UPS.”
Breaking the chains: structure and function of the deubiquitinases (2009, background): “html">Supplementary information S11 (box) for a brief description of currently available inhibitors”
The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, background): “In tumorigenesis, proteasome abnormalities are not observed; thus, the function of the proteasome in tumor cells may be on the basis of their own needs.(11) The boronic acid derivative bortezomib (Velcade, Millennium Pharmaceuticals), a unique first-in-class compound, can slowly and reversibly block”