New cell lines from mouse epiblast share defining features with human embryonic stem cells

By P. Tesar, Josh G. Chenoweth, F. Brook, T. J. Davies, E. P. Evans, David L. Mack, R. Gardner, R. McKay. Nature, 2007

2,254 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5e995a43c8f723f1fe84e4285081e63693d2b6bd

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In Molecular Biology

Citations in the corpus

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling (2009, background): “The expression of OTX2 and FGF5 before neuralization suggests the presence of epiblast-stage cells in our culture”
The promise of induced pluripotent stem cells in research and therapy (2012, background): “Human iPS-cell colonies are flatter than those of mice and are akin to a distinct type of pluripotent stem cell that is derived from the epiblast of the early mouse embry”
Induced pluripotency: history, mechanisms, and applications. (2010, background): “…derived from post-implantation embryos in the presence of bFGF and activin represent a more advanced or ‘‘primed’’ pluripotent state that exhibits some pluripotency criteria, such as teratoma formation, but fails to contribute efficiently to tissues in mice (Brons et al. 2007; Tesar et al. 2007).”
Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. (2009, neutral): “Pluripotent stem cells have also been derived from the postimplantation egg cylinder stage epiblasts of mouse and rat (Brons et al., 2007; Tesar et al., 2007).”
Capture of authentic embryonic stem cells from rat blastocysts. (2008, positive): “The 3i/2i rat ES cells express Klf4, Stella (Pgc7, Dppa3), and Rex1 (Zfp42), which discriminate ES cells from EpiSCs (Jiang et al., 2008; Tesar et al., 2007).”
Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains (2008, background): “Examples include Fgf4 and Gbx2, which are associated with the inner cell mass and specifically expressed in mouse ES cells [20,24,25].”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, methodology): “…pluripotent stem cell lines have been successively derived: epiblast-derived stem (EpiS) cells from post-implantation embryos (Brons et al., 2007; Tesar et al., 2007); embryonic germ (EG) cells from primordial germ cells (Matsui et al., 1992; Resnick et al., 1992); and multipotent germ stem…”
Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency (2014, neutral): “Because Oct4 is equally expressed betweenmouse ESCs and EpiSCs (Brons et al., 2007; Tesar et al., 2007), this marker does not distinguish a priori between naive and primed states.”
Somatic cell reprogramming and transitions between pluripotent states: facts, hypotheses, unresolved issues (2010, positive): “Independent pluripotent lines, called ‘‘EpiSCs,’’ were established by explanting the epiblast from embryonic day 5.5–7.5 of postimplantation mouse embryos in growth conditions supplemented with FGF2 (basic fibroblast growth factor) and Activin (Brons et al., 2007; Tesar et al., 2007).”
Nanog Is the Gateway to the Pluripotent Ground State (2009, neutral): “These findings suggest that Nanog choreographs synthesis of the naive epiblast ground state in the embryo and that this function is recapitulated in the culmination of somatic cell reprogramming.”
A core Klf circuitry regulates self-renewal of embryonic stem cells (2008, background): “Recent studies have generated pluripotent cell-lines from the epiblast of mouse embryo”