Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals

By J. Moskovitz, S. Bar-Noy, Wesley M. Williams, J. Requena, B. S. Berlett, E. Stadtman. Proceedings of the National Academy of Sciences of the United States of America, 2001

661 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/5e132eef00543e6ea3c6f51e8b1f2fdad79e1ed4

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Citations in the corpus

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis). (2010, neutral): “…and Harley, 1988; Phillips et al., 1989; Orr and Sohal, 1994; Parkes et al., 1998; Melov et al., 1999; Adachi and Ishii, 2000; Melov et al., 2000; Moskovitz et al., 2001; Bakaev and Lyudmila , 2002; Ruan et al., 2002; Ishii et al., 2004; Huang et al., 2006; Zou et al., 2007; Kim et al., 2008;…”
Radical-free biology of oxidative stress. (2008, background): “Two types of methionine sulfoxide reductases act on the structurally distinct S- and R-sulfoxides (65, 89, 196); methionine sulfoxide reductases activities are dependent on thioredoxins (Trx) (196) and have been associated with longevity (123, 130, 147, 152).”
An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, background): “methionine sulfoxide reductase, a enzyme that catalyzes the reduction of methionine sulfoxide back to methionine, extended life span by 70% in Drosophila (227), while mice with reduced activity of methionine sulfoxide reductase have an increased sensitivity to oxidative stress (179).”
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. (2003, background): “(23) produced mice mutated in the MsrA gene (MsrA / ), which encodes methionine sulfoxide reductase, the enzyme responsible for reducing methionine sulfoxide residues in proteins.”
How Selenium Has Altered Our Understanding of the Genetic Code (2002, background): “It has been implicated in antioxidant defense and the life span of mammals (74).”
Chemistry and biology of reactive oxygen species in signaling or stress responses (2011, background): “For example, methionine thioethers can be oxidized to the corresponding sulfoxides, and methionine sulfoxide reductase, an enzyme that is crucial for normal lifespan in mammals, can reverse this modificatio”
Trends in oxidative aging theories. (2007, background): “Concerning the dose–response argument presented in the case of Sod1 and Sod2 overexpression, it would be of interest to know the effect of a deletion of MsrA on life span, especially considering that it has been reported to shorten life span in mice [154].”
The oxidative environment and protein damage. (2005, background): “This topic area is reviewed elsewhere in this volume by Moskovitz, and also previously [152–154,157,159].”
Oxidative stress and nitration in neurodegeneration: cause, effect, or association? (2003, background): “Consistent with this view is the demonstration of decreased repair activity of methionine sulfoxide reductase, an enzymatic activity essential for repair of oxidized methionine residues, in Alzheimer disease brains (8).”
Is the Oxidative Stress Theory of Aging Dead? (2009, background): “[45] reported an ∼40% decrease in mean and maximum lifespans in MsrA−/− mice, and in 2005, Elchuri et al.”
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. (2008, background): “, 2002), while MsrA / mice show increased mortality in response to oxidant-induced aging (Moskovitz et al., 2001).”