Is the Oxidative Stress Theory of Aging Dead?
By V. Pérez, Alex F. Bokov, H. Van Remmen, James Mele, Qitao Ran, Y. Ikeno, Arlan Richardson. Biochimica et Biophysica Acta, 2009
598 citations recorded by the source corpus.
Currently, the Oxidative Stress (or Free Radical) Theory of Aging is the most popular explanation of how aging occurs at the molecular level. While data from studies in invertebrates (e.g., C. elegans and Drosophila) and rodents show a correlation between increased lifespan and resistance to oxidative stress (and in some cases reduced oxidative damage to macromolecules), direct evidence showing that alterations in oxidative damage/stress play a role in aging are limited to a few studies with transgenic Drosophila that overexpress antioxidant enzymes. Over the past eight years, our laboratory has conducted an exhaustive study on the effect of under- or overexpressing a large number and wide variety of genes coding for antioxidant enzymes. In this review, we present the survival data from these studies together. Because only one (the deletion of the Sod1 gene) of the 18 genetic manipulations we studied had an effect on lifespan, our data calls into serious question the hypothesis that alterations in oxidative damage/stress play a role in the longevity of mice.
Subfields: Aging, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/d60a72d12f84274ed90b8a04b545ffbe5f5aa0c2
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Citations in the corpus
- Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease (2019, background): “Double gene deletion combinations of SOD1 alongside another antioxidant gene resulted in reduced life expectancy of mice [133, 137].”
- Oxidative stress response and Nrf2 signaling in aging. (2015, unknown): “(see reviews [38-42]), the former point, i.”
- From bivalves to birds : oxidative stress and longevity (2010, methodology): “This approach was taken in long-term studies of mice by Pérez et al. (2009a) to show the absence of life-extending effects of antioxidant over-expression and the very limited effect of under-expression on shortening of MLSP. Finally, it would be fruitful to carry out parallel experiments on…”
- Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants (2013, background): “It seems that failures of some or all of the repair systems contributemore to aging and age-related diseases than moderate oscillations in antioxidants and ROS formation [12–14].”