Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors

By K. Honda, A. Takaoka, Tadatsugu Taniguchi. 2006

1,273 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5decb5d15e29d242ffc932d1c66160968732cb35

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Citations in the corpus

A minimal RNA ligand for potent RIG-I activation in living mice (2017, background): “Type I IFNs induce hundreds of genes, collectively known as IFN-stimulated genes (ISGs), which have a variety of antiviral effector functions (7, 8).”
Shared and Distinct Functions of Type I and Type III Interferons (2019, neutral): “In the classical model of type I IFN induction, PRR activation leads to IRF3 activation, followed by IFN-b induction (Honda et al., 2006; Paun and Pitha, 2007).”
Pattern recognition receptors and inflammation. (2010, background): “Type I IFNs, including multiple forms of IFN-a and single forms of IFN-b, IFN-u, etc., are also involved in the modulation of inflammation (Honda et al., 2006).”
MDA5/RIG-I and virus recognition. (2008, background): “Type I IFNs, comprised of multiple IFN-a isoforms and a single IFN-b, and other members, such as IFN-v, IFN-e and IFN-k, are pleiotropic cytokines that are essential for antiviral immune responses [4].”
Type I interferons in host defense. (2006, positive): “…to integrate important recent developments into the well-established framework of IFN function that is discussed in the accompanying reviews (Honda et al., 2006; van Boxel-Dezaire et al., 2006; Banchereau and Pascual, 2006) and other papers (Honda et al., 2005b; Garcia-Sastre and Biron,…”
Interferons at age 50: past, current and future impact on biomedicine (2007, background): “The most important transcription factors for induction are proteins of the IFN regulatory factor (IRF), specifi cally IRF3 and IRF7, and NFκb families 15, 16 .”
The development of inflammatory TH-17 cells requires interferon-regulatory factor 4 (2007, background): “The interferon-regulatory factors (IRFs) are a family of nine mammalian transcription factors that are key to the production of type I interfero”
Recognition of microorganisms and activation of the immune response (2007, background): “This results in antiviral immune responses in both cases, through inducing the expression of numerous IFN-inducible genes, the products of which have a broad range of antiviral activitie”