Inducing and expanding regulatory T cell populations by foreign antigen
By Karsten Kretschmer, I. Apostolou, D. Hawiger, K. Khazaie, Michel C. Nussenzweig, H. von Boehmer. Nature Immunology, 2005
1,404 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/5da5ae7ae67ddac602a31d9a3703cd9047bfe622
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In Immunology
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Citations in the corpus
- TH-17 cells in the circle of immunity and autoimmunity (2007, background): “It has been found that naive T cells stimulated in suboptimal conditions upregulate Foxp3 and differentiate into induced T reg cell”
- Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “Along the same lines, chronic systemic administration of low-dose foreign antigen results in induction of antigen-specific iTreg cells in both TCR transgenic and polyclonal T cell populations (101, 112, 113).”
- Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection (2009, background): “…level of costimulation—both events that characterize T. gondii infection (Gaddi and Yap, 2007)—had an antagonistic effect on Treg cell conversion (Benson et al., 2007; Bettelli et al., 2006; Kretschmer et al., 2005; O’Malley et al., 2009; Veldhoen et al., 2006; Wang et al., 2008; Wei et al., 2007).”
- Fat Treg cells: a liaison between the immune and metabolic systems (2009, background): “In addition, the TCR repertoire of T reg cells in the abdominal adipose tissue might give an indication of whether their abundance reflects an influx and/or a retention of cells of a particular specificity or a local cytokine-induced conversio”
- CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation (2007, background): “T reg cells can also be generated in the periphery in the context of suboptimal TCR stimulation (7).”
- IL-17 and Th17 Cells. (2009, background): “In addition, TGF-β induces the Treg-specific transcription factor Foxp3, which is required for the induction and maintenance of induced Treg cells (iTreg) in the peripheral immune compartment (64, 65).”
- Extrathymically generated regulatory T cells control mucosal Th2 inflammation (2012, background): “, whereas iT reg cells are efficiently generated upon TCR engagement with a high affinity cognate ligand under subimmunogenic condition”
- FOXP3 controls regulatory T cell function through cooperation with NFAT. (2006, positive): “Thus FOXP3 represses NFAT:AP-1 activity, not by displacing NFAT from NFAT:AP-1 composite sites as suggested previously (Schubert et al., 2001), but rather by forming a cooperative NFAT:FOXP3:DNA complex that re-sembles the cooperative NFAT:Fos:Jun:DNA complex.”
- Regulatory T cells and infection: a dangerous necessity (2007, background): “or by targeting antigen to DCs via the regulatory receptor CD205 (also known as LY75 or DEC205”