Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice

By Mathieu Ferron, E. Hinoi, G. Karsenty, P. Ducy. Proceedings of the National Academy of Sciences of the United States of America, 2008

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Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015, background): “…in vivo and in vitro studies have reported that the increase in hyaluronic acid synthesis after parathyroid hormone (PTH) treatment was related to a subsequent bone resorption [123–127] suggesting a possible relationship between hyaluronic acid synthesis and the increase in osteoclast activity.”
Endocrine regulation of male fertility by the skeleton. (2011, positive): “Osteocalcin stimulation of Leydig cells or testes explants Primary Leydig cells and testes explants were washed 3 times with PBS and stimulated with different doses of recombinant osteocalcin prepared as previously described (Ferron et al., 2008) or with hCG as a positive control.”
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism (2010, background): “increase insulin secretion to the same extent as recombinant uncarboxylated osteocalcin used as a positive control (Ferron et al., 2008) (Figure 5C).”