The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice.

By P. Bercik, Emmanuel Denou, J. Collins, W. Jackson, Jun Lu, J. Jury, Yikang Deng, P. Blennerhassett, J. Macri, K. McCoy and 2 more. Gastroenterology, 2011

1,657 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Gastroenterology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5c7552f85b0cf29f92c8e663c3be5a1207f6b7fc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. J. Foster
5. L. Rinaman
6. P. Kennedy
7. C. Stanton
8. S. Mazmanian

In Gastroenterology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. R. Stilling
5. P. Kennedy
6. J. Foster
7. Emeran A. Mayer
8. L. Rinaman

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. S. Mazmanian
5. C. Stanton
6. Yan Wang
7. L. Kasper
8. T. Sampson

Citations in the corpus

• Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018, result): “In line with that, in a model of chronic colitis associated to anxiety-like behavior, the anxiolytic effect obtained with a treatment with Bifidobacterium longum, was absent in mice that were vagotomized before the induction of colitis (132).”
• Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease (2016, positive): “The microbiota regulate expression of the 5-hydroxytryptamine receptor (5-HT1A), brain-derived neurotropic factor (BDNF), and NMDA receptor subunit 2 (NR2A) (Bercik et al., 2011; Diaz Heijtz et al., 2011; Sudo et al., 2004).”
• Gut microbiota are related to Parkinson's disease and clinical phenotype (2015, background): “Further possible mechanisms for microbiome–host interactions in PD could involve neurotoxins, neurotrophic factors, and neurotransmitters.(26,29,30,78,79) However, the relevance of the above-mentioned pathways with regard to PD remains unclear.”
• The role of microbiome in central nervous system disorders (2013, positive): “For example, B. longum NCC3001 can normalize murine hippocampal BDNF expression and L. rhamnosus (JB-1) can exert differential regulation of GABA transcription in different CNS regions (Bercik et al., 2011b; Bravo et al., 2011).”
• Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis (2014, background): “…of a different mouse strains is mainly responsible for variations in their gut microbiota (Kovacs et al. 2011) and adoptive transfer of phenotypic strain differences by microbiota transplantations or inter-strain cross-fostering (Bercik et al. 2011a; Collins et al. 2013; Francis et al. 2003).”
• Intestinal microbiota in functional bowel disorders: a Rome foundation report (2012, background): “61 Transient perturbation of the microbiota with antimicrobials alters brain-derived neurotrophic factor expression, exploratory behaviour and colonisation of germfree mice suggesting that intestinal microbiota impact is not limited to the gut and the immune system, but may involve the central nervo”
• The Central Nervous System and the Gut Microbiome (2016, background): “A reciprocal effect by gut bacteria has been reported as well, where specific bacteria, or complete microbial assemblages, had effects on host stress- and depression-like behaviors (Bercik et al., 2011a; Gacias et al., 2016; Sudo et al., 2004).”
• The Hologenome Concept: Human, Animal and Plant Microbiota (2014, background): “8-fold higher in conventional mice than germ-free animals (Bercik et al. 2011).”
• Stress and Obesity. (2019, background): “For example, transferring gut microbiota from stress-prone mice to normal mice induces anxiety-related behaviors, and doing the opposite—transferring gut microbiota from normal mice to stress-prone mice—induces reduction in anxiety (Bercik et al. 2011).”