Neurovascular mechanisms of Alzheimer's neurodegeneration.

By Berislav Zlokovic. Trends in Neurosciences, 2005

955 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/5c2f9b7dce4f106bad700091f3dddd152d7c1738

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. D. Holtzman
2. Berislav Zlokovic
3. R. Bell
4. N. Abbott
5. A. Sagare
6. R. Deane
7. S. Debette
8. H. Markus

In Neurology

1. Berislav Zlokovic
2. Maiken Nedergaard
3. N. Abbott
4. R. Bell
5. J. Attems
6. A. Sagare
7. K. Jellinger
8. D. Holtzman

In Physiology

1. Berislav Zlokovic
2. D. Holtzman
3. A. Sagare
4. R. Bell
5. J. Attems
6. R. Deane
7. K. Jellinger
8. N. Abbott

Citations in the corpus

• Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury (2014, background): “These changes within perivascular domains are associated with the impairment of interstitial amyloidclearance (Zlokovic, 2005; Kress et al., 2014), suggesting that disruption of perivascular cellular function may render the aging brain vulnerable to misaggregation of amyloid- and other proteins, and”
• Age-Associated Reductions in Cerebral Blood Flow Are Independent from Regional Atrophy (2010, background): “…Dai et al., 2008c, 2009; Uh et al., 2010) suggest vascular contributions to Alzheimer's disease (AD) and other dementia (Bell and Zlokovic, 2009; Caroli et al., 2007; de la Torre, 2005; Dickstein et al., 2010; Helzner et al., 2009; Ruitenberg et al., 2005; Sachdev et al., 1999; Zlokovic, 2005).”
• Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions (2006, background): “It was suggested that impaired clearance of β-amyloid across the BBB, aberrant angiogenesis, and senescence of the cerebrovascular system could initiate neurovascular uncoupling, brain hypoperfusion, and neurovascular inflammation (Zlokovic 2005).”
• 3D Self-Organized Microvascular Model of the Human Blood-Brain Barrier with Endothelial Cells, Pericytes and Astrocytes (2018, background): “Loss of BBB integrity is associated with Alzheimer's disease [4,5], Parkinson's disease [6], and multiple sclerosis [7], as well as with brain cancer [8].”
• The blood-brain barrier in brain homeostasis and neurological diseases. (2009, neutral): “Although BBB has long been dismissed in this type of CNS disease, recent data strongly suggested that BBB dysfunction might contribute to disease progression [181 – 183].”
• Structure and function of the blood-brain barrier. (2010, background): “Berzin et al., 2000 Kalaria, 1999 Cirrito et al., 2005 Tai et al., 2009 Zlokovic, 2005 Bell and Zlokovic, 2009 Parkinson's disease Dysfunction of the BBB by reduced efficacy of P-glycoprotein.”
• Astrocyte-mediated control of cerebral blood flow (2006, background): “Chronic inability to increase blood flow in response to increased energy demands may, in the long term, contribute to neuronal dysfunction and deat”
• Alzheimer’s Disease and the β-Amyloid Peptide (2010, neutral): “However, it is possible that the disruption of these mechanisms, coupled with other extensive co-morbid vascular abnormalities within the AD brain, contribute significantly to and are affected by the development of amyloid pathology [68].”
• The overlap between vascular disease and Alzheimer’s disease - lessons from pathology (2014, background): “CVD has been suggested to contribute to AD neuropathological changes including selective brain atrophy and accumulation of abnormal proteins such as Aβ [24,35,84,85].”
• The blood-brain barrier in health and chronic neurodegenerative disorders. (2008, positive): “Brain ISF-CSF ‘‘bulk flow’’ mediates transport of molecules into the CSF at a slow rate, irrespective of their size (Davson, 1976; Zlokovic, 2005).”
• The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis (2010, background): “Secondly, white matter hyperintensities could interact with pathological changes related to Alzheimer’s disease and thereby accelerate their clinical expression, or vice versa.”
• Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease (2009, background): “These large arteries travel through the dura mater branching into the leptomeningeal or pial arteries that travel on the surface of the brain in the subarachnoid space [104].”